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Multidimensional liquid-phase separations combining both chromatography and electrophoresis - A review

Ranjbar, L, Foley, JP and Breadmore, MC ORCID: 0000-0001-5591-4326 2017 , 'Multidimensional liquid-phase separations combining both chromatography and electrophoresis - A review' , Analytica Chimica Acta, vol. 950 , pp. 7-31 , doi: 10.1016/j.aca.2016.10.025.

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Abstract

Described as intrinsically powerful building blocks for two-dimensional separations by Giddings [Anal. Chem., 56 (1984) 1258A–1270A], the coupling of chromatography and electrophoresis has been proven to enhance the resolution of a wide array of molecules in complex biological, environmental and food samples. This review provides a comprehensive overview of multidimensional chromato-electrophoretic (LC - E) and electrophero-chromatographic (E - LC) separation systems from inception to the most recent published examples. LC separation modes include reversed phase, ion exchange, and size exclusion. Electromigration separation modes include capillary, microchip or free flow electrophoresis; micellar electrokinetic chromatography; electrochromatography; and isoelectric focusing. The advantages and disadvantages of various non-gel based off-line and on-line hyphenation technologies of LC - E and E - LC are discussed, with conditions and system characteristics also provided.

Item Type: Article
Authors/Creators:Ranjbar, L and Foley, JP and Breadmore, MC
Keywords: chromatography, electrophoresis, two-dimensional liquid chromatography electrophoresis, two-dimensional electrophoresis-liquid chromatography, comprehensive, heart-cutting, analytical chemistry
Journal or Publication Title: Analytica Chimica Acta
Publisher: Elsevier Science Bv
ISSN: 0003-2670
DOI / ID Number: 10.1016/j.aca.2016.10.025
Copyright Information:

Copyright 2016 Elsevier B.V.

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