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Sphingomyelin is involved in multisite musculoskeletal pain: evidence from metabolomic analysis in two independent cohorts

Pan, F ORCID: 0000-0002-3403-0094, Liu, M, Randell, EW, Rahman, P, Jones, G ORCID: 0000-0002-9814-0006 and Zhai, G 2020 , 'Sphingomyelin is involved in multisite musculoskeletal pain: evidence from metabolomic analysis in two independent cohorts' , Pain , pp. 1-6 , doi: 10.1097/j.pain.0000000000002163.

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Abstract

Metabolic dysfunction has been suggested to be involved in musculoskeletal pain; however, few studies have identified metabolic markers associated with multisite musculoskeletal pain (MSMP). This study sought to identify metabolic marker(s) for MSMP by metabolomic analysis. The Tasmanian Older Adult Cohort Study (TASOAC) provided the discovery cohort with the Newfoundland Osteoarthritis Study (NFOAS) providing the replication cohort. MSMP was assessed by a self-reported pain questionnaire and defined as painful sites ≥4 in both TASOAC and NFOAS. Further, MSMP was also defined as painful sites ≥7, while non-MSMP was defined as either painful sites p<0.03). Our findings suggest that sphingomyelin metabolism is involved in the pathogenesis of MSMP and circulating level of SM C18:1 could serve as a potential marker in the management of MSMP.

Item Type: Article
Authors/Creators:Pan, F and Liu, M and Randell, EW and Rahman, P and Jones, G and Zhai, G
Keywords: multisite musculoskeletal pain, metabolomics, biomarker, Sphingomyelin
Journal or Publication Title: Pain
Publisher: Elsevier Science Bv
ISSN: 0304-3959
DOI / ID Number: 10.1097/j.pain.0000000000002163
Copyright Information:

Copyright 2021 International Association for the Study of Pain

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