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Urate and risk of Alzheimer's disease and vascular dementia: A population-based study

Scheepers, LEJM ORCID: 0000-0001-6792-8506, Jacobsson, LTH, Kern, S, Johansson, L, Dehlin, M and Skoog, I 2019 , 'Urate and risk of Alzheimer's disease and vascular dementia: A population-based study' , Alzheimer's & Dementia, vol. 15, no. 6 , pp. 754-763 , doi: 10.1016/j.jalz.2019.01.014.

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Abstract

Introduction: Low serum urate (sU) has been suggested to increase the risk of dementia since areduction might impair antioxidant capacity. On the other hand, high sU is associated with increasedcardiovascular risk which might increase the risk of dementia, especially for vascular dementia.Methods: In 1968–1969, a population-based sample of 1462 women aged 38 to 60 years was examined and were followed up over 44 years (mean 33.1 years). We examined whether sU (determined in1968–1969 and 1992–1994) is associated with risk of late-life dementia.Results: During 44 years of follow-up, a higher sU (per standard deviation of 76.5 mmol/L) was associated with lower risk for dementia (n 5 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72–0.91), Alzheimer’s disease (n 5 152; HR 0.78; CI 0.66–0.91), and vascular dementia (n 5 52; HR0.66; CI 0.47–0.94).Discussion: Our findings support the hypothesis that sU has a protective role in the development ofdementia, regardless of dementia subtype. This may have important implications in the treatment ofdementia and treatment goals for hyperuricemia in patients with gout.

Item Type: Article
Authors/Creators:Scheepers, LEJM and Jacobsson, LTH and Kern, S and Johansson, L and Dehlin, M and Skoog, I
Keywords: dementia, alzheimer's, vascular dementia, urate, uric acid, gout
Journal or Publication Title: Alzheimer's & Dementia
Publisher: John Wiley & Sons Ltd.
ISSN: 1552-5260
DOI / ID Number: 10.1016/j.jalz.2019.01.014
Copyright Information:

Copyright 2019 the Alzheimer’s Association

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