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An open microfluidic chip for continuous sampling of solute from a turbulent particle suspension

Shallan, AI, Tavares, Y, Navvab Kashani, M, Breadmore, MC ORCID: 0000-0001-5591-4326 and Priest, C 2021 , 'An open microfluidic chip for continuous sampling of solute from a turbulent particle suspension' , Angewandte Chemie - International Edition, vol. 60, no. 5 , pp. 2654-2657 , doi: 10.1002/anie.202012410.

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Abstract

High solids content complicates in situ analysis of chemical processing, biological suspensions, and environmental streams. In most cases, analytical methods require at least one pre‐treatment step of a small volume of sample before a particle‐free fluid can be analyzed. We have developed a continuous in situ sampler that can "sip" particle‐free solution from a turbulent high solids content stream (a slurry). An open microfluidic chip with an extended slit opening shields the internal laminar flow from the turbulence outside. Unlike other open chips, our chip does not require close proximity to a solid surface and operates in turbulent environments for hours without maintenance. Two applications are demonstrated: monitoring FeIII in a stirred slurry of mixed ore particles at high solids loading (4 %wt) and paracetamol tablet dissolution profiles for two different formulations.

Item Type: Article
Authors/Creators:Shallan, AI and Tavares, Y and Navvab Kashani, M and Breadmore, MC and Priest, C
Keywords: analytical chemistry
Journal or Publication Title: Angewandte Chemie - International Edition
Publisher: Wiley-V C H Verlag Gmbh
ISSN: 1433-7851
DOI / ID Number: 10.1002/anie.202012410
Copyright Information:

Copyright 2020 Wiley-VCH GmbH

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