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Spontaneous tumor regression in Tasmanian devils associated with RASL11A activation

Margres, MJ, Ruiz Aravena, M, Hamede, R ORCID: 0000-0003-1526-225X, Chawla, K, Patton, AH, Lawrance, MF, Fraik, AK, Stahlke, AR, Davis, BW, Ostrander, EA, Jones, ME ORCID: 0000-0001-7558-9022, McCallum, H, Paddison, PJ, Hohenlohe, PA, Hockenbery, D and Storfer, A 2020 , 'Spontaneous tumor regression in Tasmanian devils associated with RASL11A activation' , Genetics, vol. 215, no. 4 , pp. 1143-1152 , doi: 10.1534/genetics.120.303428.

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Spontaneous tumor regression has been documented in a small proportion of human cancer patients, but the specificmechanisms underlying tumor regression without treatment are not well understood. Tasmanian devils are threatened with extinctionfrom a transmissible cancer due to universal susceptibility and a near 100% case fatality rate. In over 10,000 cases, RASL11Asignificantly contributes to tumor regression. RASL11A was expressed in regressed tumors but silenced in wild-type, nonregressedtumors, consistent with RASL11A downregulation in human cancers. Induced RASL11A expression significantly reduced tumor cellproliferation in vitro. The RAS pathway is frequently altered in human cancers, and RASL11A activation may provide a therapeutictreatment option for Tasmanian devils as well as a general mechanism for tumor inhibition.

Item Type: Article
Authors/Creators:Margres, MJ and Ruiz Aravena, M and Hamede, R and Chawla, K and Patton, AH and Lawrance, MF and Fraik, AK and Stahlke, AR and Davis, BW and Ostrander, EA and Jones, ME and McCallum, H and Paddison, PJ and Hohenlohe, PA and Hockenbery, D and Storfer, A
Keywords: Tasmanian devil, disease, genomics, DFTD, tumour, transmissible cancer, tumor regression, tumor suppressor, gene expression
Journal or Publication Title: Genetics
Publisher: Oxford University Press
ISSN: 1943-2631
DOI / ID Number: 10.1534/genetics.120.303428
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Copyright © 2020 by the Genetics Society of America

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