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Anodal transcranial direct current stimulation over the ventromedial prefrontal cortex enhances fear extinction in healthy humans: a single blind sham-controlled study

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Vicario, CM ORCID: 0000-0001-7557-9078, Nitsche, MA, Hoysted, I, Yavari, F, Avenanti, A, Salehinejad, MA and Felmingham, KL 2020 , 'Anodal transcranial direct current stimulation over the ventromedial prefrontal cortex enhances fear extinction in healthy humans: a single blind sham-controlled study' , Brain stimulation, vol. 13, no. 2, Mar , pp. 489-491 , doi: 10.1016/j.brs.2019.12.022.

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Abstract

Anxiety disorders are among the most common mental disorders[1,2]. Fear extinction is considered essential to promote successfultreatment of several anxiety disorders. Neuroscienceresearch has provided evidence for the contribution of the ventromedialprefrontal cortex (vmPFC) in extinction learning and recall[3,4]. Its role in fear extinction has been investigated via transcranialdirect current stimulation (tDCS) in a recent sham-controlledstudy involving healthy participants. In that study [5], 5 minutesof 2 mA anodal stimulation over the left vmPFC during fear extinctionreduced the physiological expression of fear (reduction of Skinconductance response - SCR) induced via Pavlovian conditioning.However, no effects were reported for the recall session.

Item Type: Article
Authors/Creators:Vicario, CM and Nitsche, MA and Hoysted, I and Yavari, F and Avenanti, A and Salehinejad, MA and Felmingham, KL
Journal or Publication Title: Brain stimulation
Publisher: Elsevier Inc.
ISSN: 1935-861X
DOI / ID Number: 10.1016/j.brs.2019.12.022
Copyright Information:

Copyright 2019 Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/

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