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Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)

Liu, A, Pirozzi, I, Codabaccus, BM ORCID: 0000-0001-5108-373X, Stephens, F, Francis, DS, Sammut, J and Booth, MA 2021 , 'Effects of dietary choline on liver lipid composition, liver histology and plasma biochemistry of juvenile yellowtail kingfish (Seriola lalandi)' , British Journal of Nutrition, vol. 125, no. 12 , pp. 1344-1358 , doi: 10.1017/S0007114520003669.

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Abstract

Choline plays a crucial role in lipid metabolism for fish, and its deficiency in aquafeed has been linked to compromised health and growth performance. A 56-d experiment was conducted to examine the effects of dietary choline on lipid composition, histology and plasma biochemistry of yellowtail kingfish (Seriola lalandi; YTK; 156 g initial body weight). The dietary choline content ranged from 0·59 to 6·22 g/kg diet. 2-Amino-2-methyl-1-propanol (AMP) (3 g/kg) was added to diets, except for a control diet, to limit de novo choline synthesis. The results showed that the liver lipid content of YTK was similar among diets containing AMP and dominated by NEFA. In contrast, fish fed the control diet had significantly elevated liver TAG. Generally, the SFA, MUFA and PUFA content of liver lipid in fish fed diets containing AMP was not influenced by choline content. The SFA and MUFA content of liver lipid in fish fed the control diet was similar to other diets except for a decrease in PUFA. The linear relationship between lipid digestibility and plasma cholesterol was significant, otherwise most parameters were unaffected. When AMP is present, higher dietary choline reduced the severity of some hepatic lesions. The present study demonstrated that choline deficiency affects some plasma and liver histology parameters in juvenile YTK which might be useful fish health indicators. Importantly, the present study elucidated potential reasons for lower growth in choline-deficient YTK and increased the knowledge on choline metabolism in the fish.

Item Type: Article
Authors/Creators:Liu, A and Pirozzi, I and Codabaccus, BM and Stephens, F and Francis, DS and Sammut, J and Booth, MA
Keywords: choline metabolism, lipid classes, fatty acids, plasma lipids, hepatic lesion, 2-Amino-2-methyl-1-propanol
Journal or Publication Title: British Journal of Nutrition
Publisher: C A B I Publishing
ISSN: 0007-1145
DOI / ID Number: 10.1017/S0007114520003669
Copyright Information:

© The Author(s), 2020. Published by Cambridge University Press on behalf of The Nutrition Society

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