Open Access Repository

Improving detection and management of familial hypercholesterolaemia in Australian general practice

Downloads

Downloads per month over past year

Brett, T, Chan, DC, Radford, J ORCID: 0000-0002-5751-0488, Heal, C, Gill, G, Hespe, C, Vargas-Garcia, C, Condon, C, Sheil, B, Li, IW, Sullivan, DR, Vickery, AW, Pang, J, Arnold-Reed, DE and Watts, GF 2021 , 'Improving detection and management of familial hypercholesterolaemia in Australian general practice' , Heart , doi: 10.1136/heartjnl-2020-318813.

[img]
Preview
PDF (Online first)
144506 - improv...pdf | Download (800kB)

| Preview

Abstract

Objective: Familial hypercholesterolaemia (FH) is characterised by elevated low-density lipoprotein (LDL)-cholesterol and increased risk of cardiovascular disease. However, FH remains substantially underdiagnosed and undertreated. We employed a two-stage pragmatic approach to identify and manage patients with FH in primary healthcare.Methods: Medical records for 232 139 patients who attended 15 general practices at least once in the previous 2 years across five Australian States were first screened for potential risk of FH using an electronic tool (TARB-Ex) and confirmed by general practitioner (GP) clinical assessment based on phenotypic Dutch Lipid Clinic Network Criteria (DLCNC) score. Follow-up GP consultation and management was provided for patients with phenotypic FH.Results: A total of 1843 patients were identified by TARB-Ex as at potential risk of FH (DLCNC score ≥5). After GP medical record review, 900 of these patients (49%) were confirmed with DLCNC score ≥5 and classified as high-risk of FH. From 556 patients subsequently clinically assessed by GPs, 147 (26%) were diagnosed with phenotypic FH (DLCNC score >6). Follow-up GP consultation and management for 77 patients resulted in a significant reduction in LDL-cholesterol (-16%, pConclusions: A pragmatic approach integrating electronic medical record tools and clinical GP follow-up consultation is a feasible method to identify and better manage patients with FH in the primary healthcare setting.

Item Type: Article
Authors/Creators:Brett, T and Chan, DC and Radford, J and Heal, C and Gill, G and Hespe, C and Vargas-Garcia, C and Condon, C and Sheil, B and Li, IW and Sullivan, DR and Vickery, AW and Pang, J and Arnold-Reed, DE and Watts, GF
Keywords: Familial Hypercholesterolaemia, general practice, preventive healthcare, atherosclerotic cardiovascular disease, cascade testing,
Journal or Publication Title: Heart
Publisher: B M J Publishing Group
ISSN: 1355-6037
DOI / ID Number: 10.1136/heartjnl-2020-318813
Copyright Information:

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP