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Cross-sectional and temporal differences in health-related quality of life of people with and without osteoarthritis: a 10-year prospective study

Zhao, T, Ahmad, H ORCID: 0000-0002-2580-9856, Winzenberg, T ORCID: 0000-0002-4112-3491, Aitken, D ORCID: 0000-0001-5685-7634, de Graaff, B ORCID: 0000-0003-0743-9561, Jones, G ORCID: 0000-0002-9814-0006 and Palmer, AJ ORCID: 0000-0002-9703-7891 2020 , 'Cross-sectional and temporal differences in health-related quality of life of people with and without osteoarthritis: a 10-year prospective study' , Rheumatology , pp. 1-8 , doi: 10.1093/rheumatology/keaa787.

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Objective: To describe the impact of OA on health-related quality of life (HRQoL) in the forms of health state utilities (HSUs) and health-dimension scores, and to compare the longitudinal changes in HRQoL for people with andwithout OA, using an Australian population-based longitudinal cohort.Methods: Participants of the Tasmanian Older Adult Cohort with data on OA diagnosis and HRQoL were included[interviewed at baseline (n¼ 1093), 2.5 years (n¼ 871), 5 years (n ¼ 760) and 10 years (n ¼ 562)]. HRQoL wasassessed using the Assessment of Quality of Life four-dimensions and analysed using multivariable linear mixedregressions.Results: Compared with participants without OA, HSUs for those with OA were 0.07 (95% confidence interval:0.09, 0.05) units lower on average over 10 years. HSUs for participants with knee and/or hip OA were similar tothose with other types of OA at the 2.5 year follow-up and then diverged, with HSUs of the former being up to0.09 units lower than the latter. Those with OA had lower scores for psychological wellness, independent living andsocial relationships compared with those without OA. Independent living and social relationships were mainlyimpacted by knee and/or hip OA, with the effect on the former increasing over time.Conclusion: Interventions to improve HRQoL should be tailored to specific OA types, health dimensions, andtimes. Support for maintaining psychological wellness should be provided, irrespective of OA type and duration.However, support for maintaining independent living could be more relevant to knee and/or hip OA patients livingwith the disease for longer.

Item Type: Article
Authors/Creators:Zhao, T and Ahmad, H and Winzenberg, T and Aitken, D and de Graaff, B and Jones, G and Palmer, AJ
Keywords: osteoarthritis, HRQoL, HSUs, the Assessment of Quality of Life four-dimensions
Journal or Publication Title: Rheumatology
Publisher: Oxford Univ Press
ISSN: 1462-0324
DOI / ID Number: 10.1093/rheumatology/keaa787
Copyright Information:

VC The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.

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