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Effect of one-week oral or inhaled salbutamol treatment with washout on repeated sprint performance in trained subjects

Eibye, K, Jacobson, GA ORCID: 0000-0002-3409-8769, Bengtsen, K, Jessen, S, Backer, V, Bangsbo, J and Hostrup, M 2021 , 'Effect of one-week oral or inhaled salbutamol treatment with washout on repeated sprint performance in trained subjects' , Translational Sports Medicine, vol. 4 , 241–249 , doi: 10.1002/tsm2.210.

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Abstract

Background: Acute and chronic supratherapeutic treatment with the commonly usedbeta2-agonist salbutamol has the potential to enhance sprint performance and musclestrength. However, little is known about the performance effects of short-term dailypermitted inhaled treatment vs oral prohibited treatment in accordance with the 2020Prohibited List issued by the World Anti-Doping Agency (WADA).Methods: Herein, we investigated the effect of twice-daily treatment with 400 μginhaled or 4 mg oral salbutamol for 1 week on repeated sprint performance in 19healthy well-trained men and women utilizing a randomized open-label crossoverdesign. Before and after each treatment period, and a 12-16 hours washout to avoidan acute effect of salbutamol, subjects performed a repeated sprint test (3 × 30-second Wingate).Results: Neither oral nor inhaled salbutamol enhanced peak power (oral; 3.0 W; 95%CI −6.8 to 12.8 W; and inhaled; −3.8 W; 95% CI −14.3 to 6.8 W) or mean power(oral; −2.1 W; 95% CI −4.7 to 8.9 W and inhaled; −1.6 W; 95% CI −5.6 to 8.9 W)during the repeated sprint test irrespective of gender.Conclusions: These findings indicate that 1 week is insufficient for salbutamol toinduce any relevant effect on repeated sprint performance in trained individuals.

Item Type: Article
Authors/Creators:Eibye, K and Jacobson, GA and Bengtsen, K and Jessen, S and Backer, V and Bangsbo, J and Hostrup, M
Keywords: beta2-agonist, muscle doping
Journal or Publication Title: Translational Sports Medicine
Publisher: John Wiley & Sons Ltd.
ISSN: 2573-8488
DOI / ID Number: 10.1002/tsm2.210
Copyright Information:

Copyright 2020 John Wiley & Sons Ltd

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