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Ten-Year trends in the use of oral anticoagulants in Australian general practice patients with atrial fibrillation


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Bezabhe, WM ORCID: 0000-0002-3028-6949, Bereznicki, LR ORCID: 0000-0003-3974-3437, Radford, J ORCID: 0000-0002-5751-0488, Wimmer, BC ORCID: 0000-0003-3166-7126, Curtain, C ORCID: 0000-0001-5029-7541, Salahudeen, MS ORCID: 0000-0001-9131-7465 and Peterson, GM ORCID: 0000-0002-6764-3882 2021 , 'Ten-Year trends in the use of oral anticoagulants in Australian general practice patients with atrial fibrillation' , Frontiers in Pharmacology, vol. 12 , doi: 10.3389/fphar.2021.586370.

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Objective: Appropriate use of oral anticoagulants (OACs) reduces the risk of stroke in patients with atrial fibrillation (AF). The study characterized the prescribing of OACs inpeople with AF in the Australian primary care setting over 10 years.Design: Retrospective population study.Setting and Participants: We performed 10 sequential cross-sectional analyses ofpatients with a recorded diagnosis of AF between 2009 and 2018 using national generalpractice data. The proportion of patients with AF who were prescribed an OAC based ontheir stroke risk was examined.Primary and secondary outcomes: The primary outcome was the proportion of highstroke risk patients who were prescribed an OAC over a decade. The secondary outcomewas variation in OAC prescribing among general practices.Results: The sample size of patients with AF ranged from 9,874 in 2009 to 41,751 in 2018.The proportion who were prescribed an OAC increased from 39.5% (95% CI 38.6–40.5%)in 2009 to 52.0% (95% CI 51.5–52.4%) in 2018 (p for trend Conclusions: Over the 10 years, OAC prescribing in high stroke risk patients with AFincreased by one-third. There was considerable variation in OAC prescribing betweengeneral practices.

Item Type: Article
Authors/Creators:Bezabhe, WM and Bereznicki, LR and Radford, J and Wimmer, BC and Curtain, C and Salahudeen, MS and Peterson, GM
Keywords: trends, anticoagulants, atrial fibrillation, general practice, primary care, Australia
Journal or Publication Title: Frontiers in Pharmacology
Publisher: Frontiers Research Foundation
ISSN: 1663-9812
DOI / ID Number: 10.3389/fphar.2021.586370
Copyright Information:

Copyright 2021 Bezabhe, Bereznicki, Radford, Wimmer, Curtain, Salahudeen andPeterson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

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