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The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders

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Chong, WC, Shastri, MD ORCID: 0000-0002-1012-2779, Peterson, GM ORCID: 0000-0002-6764-3882, Patel, RP ORCID: 0000-0001-9344-1013, Pathinayake, PS, Dua, K, Hansbro, NG, Hsu, AC, Wark, PA, Shukla, SD, Johansen, MD, Schroder, K and Hansbro, PM 2021 , 'The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders' , Clinical & Translational Immunology, vol. 10 , pp. 1-16 , doi: 10.1002/cti2.1247.

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Abstract

Inflammation is the result of a complex network of cellular and molecular interactions and mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli, particularly pathogens, to maintain homeostasis and promote tissue healing. However, dysregulation in the immune system elicits excess/abnormal inflammation resulting in unintended tissue damage and causes major inflammatory diseases including asthma, chronic obstructive pulmonary disease, atherosclerosis, inflammatory bowel diseases, sarcoidosis and rheumatoid arthritis. It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades. Notably, evidence is mounting for the involvement of ER stress in exacerbating inflammasome‐induced inflammatory cascades, which may provide a new axis for therapeutic targeting in a range of inflammatory disorders. Here, we comprehensively review the roles, mechanisms and interactions of both ER stress and inflammasomes, as well as their interconnected relationships in inflammatory signalling cascades. We also discuss novel therapeutic strategies that are being developed to treat ER stress‐ and inflammasome‐related inflammatory disorders.

Item Type: Article
Authors/Creators:Chong, WC and Shastri, MD and Peterson, GM and Patel, RP and Pathinayake, PS and Dua, K and Hansbro, NG and Hsu, AC and Wark, PA and Shukla, SD and Johansen, MD and Schroder, K and Hansbro, PM
Keywords: endoplasmic reticulum stress, inflammasome,inflammatory disorder, NLRP3
Journal or Publication Title: Clinical & Translational Immunology
Publisher: John Wiley & Sons Ltd.
ISSN: 2050-0068
DOI / ID Number: 10.1002/cti2.1247
Copyright Information:

Copyright 2021 The Authors. This is an open access article under theterms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permitsuse and distribution in any medium, providedthe original work is properly cited, the use isnon‐commercial and no modifications oradaptations are made.

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