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Abstract

Objective: To compare the visual outcomes of intravitreal antivascular endothelial growth factor (anti-VEGF) injections in neovascular age-related macular degeneration (nAMD), diabetic macular oedema (DMO) and retinal vein occlusion (RVO) in a real-world setting.Methods and analysis: Retrospective analysis of data from the Tasmanian Ophthalmic Biobank database. The median change in best-corrected visual acuity (BCVA) between baseline and 12 months post initiating intravitreal anti-VEGF treatment were compared between the three diseases. Final BCVA, central macular thickness (CMT), cumulative number of injections and overall predictors of change in BCVA and CMT were also determined.Results: At 12 months, change in BCVA was significantly different between nAMD, DMO and RVO cohorts (p=0.032), with lower median change for DMO (2 letters, range -5 to 20) than for RVO (11 letters, range -20 to 35). Likewise, CMT change was significantly different between the three cohorts (p=0.022), with a smaller reduction in CMT in DMO (-54 µm, range -482 to 50) than RVO patients (-137 µm, range -478 to 43; p=0.033). Total number of injections received (p=0.028) and final BCVA score (p=0.024) were also significantly different between the groups. Baseline BCVA was a negative predictor (p=0.042) and baseline CMT a positive predictor (pConclusions:At the end of 12 months, nAMD and RVO cohorts had the greatest improvement in BCVA, however the final BCVA for DMO was significantly better than for nAMD.

Item Type:	Article
Authors/Creators:	Gurung, RL and Fitzgerald, LM and McComish, BJ and Hewitt, AW and Verma, N and Burdon, KP
Keywords:	angiogenesis, vision, anti-VEGF, neovascular age-related macular degeneration, diabetic macular oedema, retinal vein occlusion
Journal or Publication Title:	BMJ Open Ophthalmology
Publisher:	BMJ Publishing Group Ltd.
ISSN:	2397-3269
DOI / ID Number:	10.1136/bmjophth-2021-000749
Copyright Information:	Copyright 2021 the Author(s) or their employer(s). Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
Related URLs:	Google Scholar: Fitzgerald, LM Google Scholar: McComish, BJ Google Scholar: Hewitt, AW UTAS Profile: Hewitt, AW Google Scholar: Burdon, KP UTAS Profile: Burdon, KP
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