Open Access Repository

The association between maternal smoking in pregnancy, other early life characteristics and childhood vision: The twins eye study in Tasmania


Downloads per month over past year

Ponsonby, AL, Brown, SA, Kearns, LS, MacKinnon, JR, Scotter, LW, Cochrane, JA and Mackey, DA 2007 , 'The association between maternal smoking in pregnancy, other early life characteristics and childhood vision: The twins eye study in Tasmania' , Ophthalmic Epidemiology, vol. 14, no. 6 , pp. 351-359 , doi: 10.1080/01658100701486467.

[img] PDF
3691.pdf | Request a copy
Full text restricted
Available under University of Tasmania Standard License.


Purpose: To investigate the association between maternal smoking in pregnancy, early-life environment and childhood vision. Methods: Twin and triplet children enrolled in the Twins Eye Study in Tasmania underwent a comprehensive ophthalmic examination and their parents/guardians retrospectively answered a questionnaire regarding crawling, walking and other measures. A subset of these twins was also in the Tasmanian Infant Health Survey, which prospectively collected data on antenatal smoking, gestation, birth weight and other factors. Results: The mean age of the 346 individuals (172 multiple birth sets) at the time of examination was 9.25 ± 2.4 years. Mean unaided visual acuity was 0.0 (6/6). The mean spherical equivalent was +0.87D, and decreased with increasing child age (p < 0.01). A prospective analysis, accounting for birth set clustering and relevant confounders, showed increasing levels of maternal smoking in the third trimester was associated with poor stereoacuity on the Titmus test (worse (>) than 100'', p = 0.05) and Lang test (p = 0.001) and also with the presence of esotropia (p = 0.02). These associations persisted after adjustment for infant postnatal smoke exposure at one month of age. Poor stereoacuity on Titmus stereo test circles was associated with late age of first crawling (RR = 1.23 (1.06, 1.42) p = 0.005 per month) and late age of first walking (RR 1.18 (1.05, 1.22) p = 0.001 per month). Conclusions: Antenatal smoking was independently associated with poor stereovision and the presence of esotropia. Poor stereoacuity may be associated with delayed age at first crawling or walking.

Item Type: Article
Authors/Creators:Ponsonby, AL and Brown, SA and Kearns, LS and MacKinnon, JR and Scotter, LW and Cochrane, JA and Mackey, DA
Keywords: Visual acuity; Binocular function; Antenatal smoking; Stereoacuity strabismus
Journal or Publication Title: Ophthalmic Epidemiology
ISSN: 0928-6586
DOI / ID Number: 10.1080/01658100701486467
Additional Information:

The definitive version is available online at

Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page