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Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators

Shastri, M ORCID: 0000-0002-1012-2779, Chong, WC, Dua, K, Peterson, GM ORCID: 0000-0002-6764-3882, Patel, RP ORCID: 0000-0001-9344-1013, Mahmood, MQ, Tambuwala, M, Chellappan, DK, Hansbro, NG, Shukla, SD and Hansbro, PM 2020 , 'Emerging concepts and directed therapeutics for the management of asthma: regulating the regulators' , Inflammopharmacology, vol. 29, no. 1 , pp. 15-33 , doi: 10.1007/s10787-020-00770-y.

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Abstract

Asthma is a common, heterogeneous and serious disease, its prevalence has steadily risen in most parts of the world, and thecondition is often inadequately controlled in many patients. Hence, there is a major need for new therapeutic approaches.Mild-to-moderate asthma is considered a T-helper cell type-2-mediated infammatory disorder that develops due to abnormalimmune responses to otherwise innocuous allergens. Prolonged exposure to allergens and persistent infammation resultsin myofbroblast infltration and airway remodelling with mucus hypersecretion, airway smooth muscle hypertrophy, andexcess collagen deposition. The airways become hyper-responsive to provocation resulting in the characteristic wheezingand obstructed airfow experienced by patients. Extensive research has progressed the understanding of the underlyingmechanisms and the development of new treatments for the management of asthma. Here, we review the basis of the disease, covering new areas such as the role of vascularisation and microRNAs, as well as associated potential therapeuticinterventions utilising reports from animal and human studies. We also cover novel drug delivery strategies that are beingdeveloped to enhance therapeutic efcacy and patient compliance. Potential avenues to explore to improve the future ofasthma management are highlighted.

Item Type: Article
Authors/Creators:Shastri, M and Chong, WC and Dua, K and Peterson, GM and Patel, RP and Mahmood, MQ and Tambuwala, M and Chellappan, DK and Hansbro, NG and Shukla, SD and Hansbro, PM
Keywords: asthma, molecular mechanisms, vascularisation, microRNA, novel drug candidates, targeted drug delivery
Journal or Publication Title: Inflammopharmacology
Publisher: Kluwer Academic Publishers
ISSN: 0925-4692
DOI / ID Number: 10.1007/s10787-020-00770-y
Copyright Information:

Copyright 2020 Springer Nature Switzerland AG

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