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Muscle function, quality and relative mass are associated with knee pain trajectory over 10.7 years

Pan, F ORCID: 0000-0002-3403-0094, Tian, J ORCID: 0000-0001-7746-7782, Scott, D, Cicuttini, F and Jones, G ORCID: 0000-0002-9814-0006 2021 , 'Muscle function, quality and relative mass are associated with knee pain trajectory over 10.7 years' , Pain , doi: 10.1097/j.pain.0000000000002383.

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Abstract

Periarticular muscle plays an important role in the pathogenesis of musculoskeletal pain. Werecently reported that pain population consists of distinct subgroups of which the causes andmechanisms may differ. This study aimed to examine the association of lean mass, musclestrength and quality with 10.7-year pain trajectory. 947 participants from a population-basedcohort study were analysed. Dual-energy X-ray absorptiometry was used to assess lean andfat mass. Leg, knee extensor strength and lower-limb muscle quality weremeasured/calculated. Knee pain was assessed by the Western Ontario and McMaster Universities Osteoarthritis Index pain questionnaire. Radiographic knee osteoarthritis (ROA)was assessed by X-ray. Three distinct pain trajectories were identified: “Minimal pain” (53%),“Mild pain” (34%) and “Moderate pain” (13%). Higher total and lower-limb lean mass wereassociated with an increased risk of “Mild pain” and “Moderate pain” trajectories relative tothe “Minimal pain” trajectory group, but these associations became non-significant afterfurther adjustment for fat mass. Total lean mass percentage was associated with a lower riskof “Mild pain” [relative risk ratio (RRR): 0.95, 95%CI 0.92-0.98] and “Moderate pain”trajectory (RRR:0.92, 95%CI 0.87-0.96). Greater leg and knee extensor strength and musclequality were associated with “Mild pain” and “Moderate pain” trajectories (RRR:0.52-0.65,all P<0.05). Similar results were found in those with ROA. Higher lower-limb musclestrength and quality, and relative lean mass, are associated with a reduced risk of severe kneepain trajectories, suggesting that improving muscle function and composition may protectagainst persistent unfavourable knee pain courses.

Item Type: Article
Authors/Creators:Pan, F and Tian, J and Scott, D and Cicuttini, F and Jones, G
Keywords: muscle strength, lean mass, knee pain, trajectory, cohort study
Journal or Publication Title: Pain
Publisher: Elsevier Science Bv
ISSN: 0304-3959
DOI / ID Number: 10.1097/j.pain.0000000000002383
Copyright Information:

Copyright 2021 by the International Association for the Study of Pain.

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