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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
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Abstract
Birthweight is associated with health outcomes across the life course, DNA methylation maybe an underlying mechanism. In this meta-analysis of epigenome-wide association studies of8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase inmethylation (PBonferroni −7). In additional analyses in 7,278 participants, −74)and BMI in pregnancy (3/914, p = 1.13x10−3), but not with those related to folate levels inpregnancy. Whether the associations that we observe are causal or explained by confoundingor fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
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