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Abstract

Aims:To investigate the association between overweight/obesity and fatty liver index (FLI) on the odds of incident prediabetes/type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) in 2020 participants after 10 years follow up.Methods:At baseline (in 2001) 2020 participants, males and females, aged 24–39 years, were stratified according to body mass index (BMI), normal weight (2), overweight (≥25–2), or obese (≥30 kg/m2) and FLI (as high FLI ≥60 or low FLI Results:514 and 52 individuals developed prediabetes and type 2 diabetes during follow-up. Such individuals were older, with higher BMI, serum glucose, insulin, alanine aminotransferase (ALT) and triglyceride (TG) concentrations than those who did not develop prediabetes or type 2 diabetes (n = 1454). The additional presence of high FLI significantly increased the risk of developing prediabetes and type 2 diabetes above the risk of being overweight/obese. Compared with normal weight, low FLI participants, the odds of prediabetes were ∼2-fold higher and the odds of type 2 diabetes were 9–10-fold higher respectively in the overweight/obese, high FLI group. No difference was observed between normal weight, low FLI and overweight/obese and low FLI groups.Conclusions:An increased FLI significantly increases the odds of incident prediabetes, type 2 diabetes and NAFLD in individuals with overweight/obese highlighting the contributory role of liver fat accumulation in the pathophysiology of prediabetes/type 2 diabetes.

Item Type:	Article
Authors/Creators:	Cuthbertson, DJ and Koskinen, J and Brown, E and Magnussen, CG and Hutri-Kahonen, N and Sabin, M and Tossavainen, P and Jokinen, E and Laitinen, T and Viikari, J and Raitakari, OT and Juonala, M
Keywords:	non-alcoholic fatty liver disease, metabolic syndrome, obesity, risk, type 2 diabetes
Journal or Publication Title:	Annals of Medicine
Publisher:	Informa Healthcare
ISSN:	0785-3890
DOI / ID Number:	10.1080/07853890.2021.1956685
Copyright Information:	Copyright 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Related URLs:	Google Scholar: Magnussen, CG UTAS Profile: Magnussen, CG
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