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Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

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Bond, ST, King, EJ, Henstridge, DC ORCID: 0000-0003-4988-767X, Tran, A, Moody, SC, Yang, C, Liu, Y, Mellett, NA, Nath, AP, Inouye, M, Tarling, EJ, de Aguiar Vallim, TQ, Meikle, PJ, Calkin, AC and Drew, BG 2021 , 'Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance' , Nature Communications, vol. 12, no. 1 , pp. 1-13 , doi: 10.1038/s41467-020-20434-3.

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Abstract

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have been implicated in WAT lipid metabolism, including tripartite motif containing 28 (Trim28), a gene proposed to primarily influence adiposity via epigenetic mechanisms in embryonic development. However, in the current study we demonstrate that mice with deletion of Trim28 specifically in committed adipocytes, also develop obesity similar to global Trim28 deletion models, highlighting a post-developmental role for Trim28. These effects were exacerbated in female mice, contributing to the growing notion that Trim28 is a sex-specific regulator of obesity. Mechanistically, this phenotype involves alterations in lipolysis and triglyceride metabolism, explained in part by loss of Klf14 expression, a gene previously demonstrated to modulate adipocyte size and body composition in a sex-specific manner. Thus, these findings provide evidence that Trim28 is a bona fide, sex specific regulator of post-developmental adiposity and WAT function.

Item Type: Article
Authors/Creators:Bond, ST and King, EJ and Henstridge, DC and Tran, A and Moody, SC and Yang, C and Liu, Y and Mellett, NA and Nath, AP and Inouye, M and Tarling, EJ and de Aguiar Vallim, TQ and Meikle, PJ and Calkin, AC and Drew, BG
Keywords: obesity, adiposity, metabolism
Journal or Publication Title: Nature Communications
Publisher: Nature Pub. Group
ISSN: 2041-1723
DOI / ID Number: 10.1038/s41467-020-20434-3
Copyright Information:

© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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