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Significant cognitive decline in Parkinson's disease exacerbates the reliance on visual feedback during upper limb reaches

Cosgrone, J, Hinder, MR ORCID: 0000-0002-5240-4790, St George, RJ ORCID: 0000-0001-6206-1069, Picardi, C, Smith, SL, Lones, MA, Jamieson, S and Alty, JE ORCID: 0000-0002-5456-8676 2021 , 'Significant cognitive decline in Parkinson's disease exacerbates the reliance on visual feedback during upper limb reaches' , Neuropsychologia, vol. 157 , doi: 10.1016/j.neuropsychologia.2021.107885.

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Abstract

While upper limb reaches are often made in a feed-forward manner, visual feedback during the movement can beused to guide the reaching hand towards a target. In Parkinson’s disease (PD), there is evidence that the utilisationof this visual feedback is increased. However, it is unclear if this is due solely to the characteristicslowness of movements in PD providing more opportunity for incorporating visual feedback to modify reachtrajectories, or whether it is due to cognitive decline impacting (feed-forward) movement planning ability. Toinvestigate this, we compared reaction times and movement times of reaches to a target in groups of PD patientswith normal cognition (PD-NC), mild cognitive impairment (PD-MCI) or dementia (PD-D), to that of controlswith normal cognition (CON-NC) or mild cognitive impairment (CON-MCI). Reaches were undertaken with fullvisual feedback (at a ‘natural’ and ‘fast-as-possible’ pace); with reduced visual feedback of the reaching limb toan illuminated target; and without any visual feedback to a remembered target with eyes closed. The PD-D group exhibited slower reaction times than all other groups across conditions, indicative of lessefficient movement planning. When reaching to a remembered target with eyes closed, all PD groups exhibitedslower movement times relative to their natural pace with full visual feedback. Crucially, this relative slowingwas most pronounced for the PD-D group, compared to the PD-MCI and PD-NC groups, suggesting that substantialcognitive decline in PD exacerbates dependence on visual feedback during upper limb reaches.

Item Type: Article
Authors/Creators:Cosgrone, J and Hinder, MR and St George, RJ and Picardi, C and Smith, SL and Lones, MA and Jamieson, S and Alty, JE
Keywords: Parkinson's, dementia, cognitive impairment, motor control, reaching
Journal or Publication Title: Neuropsychologia
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0028-3932
DOI / ID Number: 10.1016/j.neuropsychologia.2021.107885
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© 2021 Elsevier Ltd. All rights reserved.

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