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Urinary sodium is positively associated with urinary free cortisol and total cortisol metabolites in a cross-sectional sample of Australian schoolchildren aged 5-12 years and their mothers

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Torres, SJ, Grimes, C, Nowson, CA, Jayasinghe, SU, Bruce, CR, Mason, SA, He, FJ and Turner, AI 2019 , 'Urinary sodium is positively associated with urinary free cortisol and total cortisol metabolites in a cross-sectional sample of Australian schoolchildren aged 5-12 years and their mothers' , The British Journal of Nutrition, vol. 121, no. 2 , pp. 164-171 , doi: 10.1017/S0007114518003148.

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Abstract

High Na intake and chronically elevated cortisol levels are independently associated with the development of chronic diseases. In adults, high Na intake is associated with high levels of urinary cortisol. We aimed to determine the association between urinary Na and K and urinary cortisol in a cross-sectional sample of Australian schoolchildren and their mothers. Participants were a sample of Australian children (n 120) and their mothers (n 100) recruited through primary schools. We assessed Na, K, free cortisol and cortisol metabolites in one 24 h urine collection. Associations between 24 h urinary electrolytes and 24 h urinary cortisol were assessed using multilevel mixed-effects linear regression models. In children, urinary Na was positively associated with urinary free cortisol (β=0·31, 95 % CI 0·19, 0·44) and urinary cortisol metabolites (β=0·006, 95 % CI 0·002, 0·010). Positive associations were also observed between urinary K and urinary free cortisol (β=0·65, 95 % CI 0·23, 1·07) and urinary cortisol metabolites (β=0·02, 95 % CI 0·03, 0·031). In mothers, urinary Na was positively associated with urinary free cortisol (β=0·23, 95 % CI 0·01, 0·50) and urinary cortisol metabolites (β=0·008, 95 % CI 0·0007, 0·016). Our findings show that daily Na and K intake were positively associated with cortisol production in children and their mothers. Investigation of the mechanisms involved and the potential impact of Na reduction on cortisol levels in these populations is warranted.

Item Type: Article
Authors/Creators:Torres, SJ and Grimes, C and Nowson, CA and Jayasinghe, SU and Bruce, CR and Mason, SA and He, FJ and Turner, AI
Keywords: 11βHSD 11β-hydroxysteroid dehydrogenase, children, cortisol, dietary intakes, mothers, potassium, sodium, urinary electrolytes
Journal or Publication Title: The British Journal of Nutrition
Publisher: C A B I Publishing
ISSN: 0007-1145
DOI / ID Number: 10.1017/S0007114518003148
Copyright Information:

© The Authors 2018. All rights reserved.

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