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Changes in multiple sclerosis symptoms are associated with changes in work productivity of people living with multiple sclerosis

Bessing, B, Hussain, MA ORCID: 0000-0002-6012-3702, Claflin, SB ORCID: 0000-0001-6545-946X, Chen, J, Blizzard, L ORCID: 0000-0002-9541-6943, Van Dijk, P, Kirk-Brown, A, Taylor, BV and van der Mei, I ORCID: 0000-0001-9009-7472 2021 , 'Changes in multiple sclerosis symptoms are associated with changes in work productivity of people living with multiple sclerosis' , Multiple Sclerosis Journal , pp. 1-10 , doi: 10.1177/1352458521994557.

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Background: While employment rates have increased in people with multiple sclerosis (PwMS), little isknown about the longitudinal trends of work productivity.Objective: To describe the longitudinal patterns of work productivity and examine the factors associatedwith annual change of work productivity of PwMS.Methods: Study participants were employed participants of the Australian MS Longitudinal Study(AMSLS) followed from 2015 to 2019 with at least two repeated measures (n= 2121). We used linearmixed models to examine if the within-individual variations in MS symptoms are associated with changesin work productivity.Results: The mean annual change in work productivity between 2015 and 2019 was −0.23% (SD =18.68%). Not the actual severity of symptoms but rather the changes in severity of symptoms that areassociated with change in work productivity in the same year. In a multivariable model, every unit increasein mean annual change in ‘pain and sensory symptoms’, ‘feelings of anxiety and depression’, and ‘fatigueand cognitive symptoms’ were independently associated with 2.43%, 1.55% and 1.01% annual reductionsin work productivity, respectively.Conclusion: Individual changes in work productivity are largely driven by the changes in symptomseverity rather than the absolute severity. Stabilising/improving MS symptoms might improve work productivity.

Item Type: Article
Authors/Creators:Bessing, B and Hussain, MA and Claflin, SB and Chen, J and Blizzard, L and Van Dijk, P and Kirk-Brown, A and Taylor, BV and van der Mei, I
Keywords: multiple sclerosis, pain, absenteeism, presenteeism, work productivity, longitudinal, intraindividual variations
Journal or Publication Title: Multiple Sclerosis Journal
Publisher: Arnold
ISSN: 1352-4585
DOI / ID Number: 10.1177/1352458521994557
Copyright Information:

© The Author(s), 2021.

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