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Association between knee symptoms, change in knee symptoms over 6–9 years, and SF-6D health state utility among middle-aged Australians

Singh, A ORCID: 0000-0002-4618-7507, Campbell, JA ORCID: 0000-0002-1820-6758, Venn, A ORCID: 0000-0001-7090-1398, Jones, Graeme ORCID: 0000-0002-9814-0006, Blizzard, L ORCID: 0000-0002-9541-6943, Palmer, AJ ORCID: 0000-0002-9703-7891, Dwyer, T, Cicuttini, F, Ding, C ORCID: 0000-0002-9479-730X and Antony, B ORCID: 0000-0001-8704-6084 2021 , 'Association between knee symptoms, change in knee symptoms over 6–9 years, and SF-6D health state utility among middle-aged Australians' , Quality of Life Research .

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Objectives:Health state utilities (HSUs) are an input metric for estimating quality-adjusted life-years (QALY) in cost–utilityanalyses. Currently, there is a paucity of data on association of knee symptoms with HSUs for middle-aged populations.We aimed to describe the association of knee symptoms and change in knee symptoms with SF-6D HSUs and describedthe distribution of HSUs against knee symptoms’ severity.Methods:Participants (36–49-years) were selected from the third follow-up (completed 2019) of Australian ChildhoodDeterminants of Adult Health study. SF-6D HSUs were generated from the participant-reported SF-12. Association between participant-reported WOMAC knee symptoms’ severity, change in knee symptoms over 6–9 years, and HSUswere evaluated using linear regression models.Results:For the cross-sectional analysis, 1,567 participants were included; mean age 43.5 years, female 54%, BMI ± SD 27.18 ± 5.31 kg/m. Mean ± SD HSUs for normal, moderate, and severe WOMAC scores were 0.820 ± 0.120, 0.800 ± 0.120, and0.740 ± 0.130, respectively. A significant association was observed between worsening knee symptoms and HSUs inunivariable and multivariable analyses after adjustment (age and sex). HSU decrement for normal-to-severe total-WOMAC and WOMAC-pain was − 0.080 (95% CI − 0.100 to − 0.060,pConclusion:In a middle-aged population-based sample, there was an independent negative association between worse knee symptom sand SF-6D HSUs. Our findings may be used by decision-makers to define more realistic and conservative baseline and ongoing HSU values when assessing QALY changes associated with osteoarthritis interventions.

Item Type: Article
Authors/Creators:Singh, A and Campbell, JA and Venn, A and Jones, Graeme and Blizzard, L and Palmer, AJ and Dwyer, T and Cicuttini, F and Ding, C and Antony, B
Keywords: knee osteoarthritis, health state utilities, economic evaluation, SF-6D, multi-attribute utility instrument
Journal or Publication Title: Quality of Life Research
Publisher: Kluwer Academic Publ
ISSN: 0962-9343
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