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Interleukin-13: A pivotal target against influenza-induced exacerbation of chronic lung diseases

Shastri, MD ORCID: 0000-0002-1012-2779, Allam, VSRR, Shukla, SD, Jha, NK, Paudel, KR, Peterson, GM ORCID: 0000-0002-6764-3882, Patel, RP ORCID: 0000-0001-9344-1013, Hansbro, PM, Chellappan, DK and Dua, K 2021 , 'Interleukin-13: A pivotal target against influenza-induced exacerbation of chronic lung diseases' , Life Sciences, vol. 283 , pp. 1-7 , doi: 10.1016/j.lfs.2021.119871.

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Abstract

Non-communicable, chronic respiratory diseases (CRDs) affect millions of individuals worldwide. The course of these CRDs (asthma, chronic obstructive pulmonary disease, and cystic fibrosis) are often punctuated by microbial infections that may result in hospitalization and are associated with increased risk of morbidity and mortality, as well as reduced quality of life. Interleukin-13 (IL-13) is a key protein that regulates airway inflammation and mucus hypersecretion. There has been much interest in IL-13 from the last two decades. This cytokine is believed to play a decisive role in the exacerbation of inflammation during the course of viral infections, especially, in those with pre-existing CRDs. Here, we discuss the common viral infections in CRDs, as well as the potential role that IL-13 plays in the virus-induced disease pathogenesis of CRDs. We also discuss, in detail, the immune-modulation potential of IL-13 that could be translated to in-depth studies to develop IL-13-based therapeutic entities.

Item Type: Article
Authors/Creators:Shastri, MD and Allam, VSRR and Shukla, SD and Jha, NK and Paudel, KR and Peterson, GM and Patel, RP and Hansbro, PM and Chellappan, DK and Dua, K
Keywords: IL-13, chronic respiratory diseases, asthma, COPD, cystic fibrosis, COVID;IL-33, eosinophils, innate lymphoid cells
Journal or Publication Title: Life Sciences
Publisher: Pergamon-Elsevier Science Ltd
ISSN: 0024-3205
DOI / ID Number: 10.1016/j.lfs.2021.119871
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© 2021 Elsevier Inc. All rights reserved

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