Open Access Repository

Chromosomics: bridging the gap between genomes and chromosomes

Downloads

Downloads per month over past year

Deakin, JE, Potter, S, O'Neill, R, Ruiz-Herrera, A, Cioffi, MB, Eldridge, MDB, Fukui, K, Marshall Graves, JA, Griffin, D, Grutzner, F, Kratochvil, L, Miura, I, Rovatsos, M, Srikulnath, K, Wapstra, E ORCID: 0000-0002-2050-8026 and Ezaz, T 2019 , 'Chromosomics: bridging the gap between genomes and chromosomes' , Genes, vol. 10, no. 8 , pp. 1-17 , doi: 10.3390/genes10080627.

[img]
Preview
PDF (Published version)
143759 - Chromo...pdf | Download (695kB)

| Preview

Abstract

The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to provide insight into how the genome is organised into chromosomes, the position and interaction of those chromosomes in the cell, and how chromosomes and their interactions with each other change in response to environmental stimuli or over time. The intimate relationship between DNA sequence and chromosome structure and function highlights the need to integrate genomic and cytogenetic data to more comprehensively understand the role genome architecture plays in genome plasticity. We propose adoption of the term 'chromosomics' as an approach encompassing genome sequencing, cytogenetics and cell biology, and present examples of where chromosomics has already led to novel discoveries, such as the sex-determining gene in eutherian mammals. More importantly, we look to the future and the questions that could be answered as we enter into the chromosomics revolution, such as the role of chromosome rearrangements in speciation and the role more rapidly evolving regions of the genome, like centromeres, play in genome plasticity. However, for chromosomics to reach its full potential, we need to address several challenges, particularly the training of a new generation of cytogeneticists, and the commitment to a closer union among the research areas of genomics, cytogenetics, cell biology and bioinformatics. Overcoming these challenges will lead to ground-breaking discoveries in understanding genome evolution and function.

Item Type: Article
Authors/Creators:Deakin, JE and Potter, S and O'Neill, R and Ruiz-Herrera, A and Cioffi, MB and Eldridge, MDB and Fukui, K and Marshall Graves, JA and Griffin, D and Grutzner, F and Kratochvil, L and Miura, I and Rovatsos, M and Srikulnath, K and Wapstra, E and Ezaz, T
Journal or Publication Title: Genes
Publisher: Molecular Diversity Preservation International
ISSN: 2073-4425
DOI / ID Number: 10.3390/genes10080627
Copyright Information:

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. his is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP