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Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net

Bucher, EA, Collins, JM ORCID: 0000-0002-1938-2470, King, AE ORCID: 0000-0003-1792-0965, Vickers, JC ORCID: 0000-0001-5671-4879 and Kirkcaldie, MTK ORCID: 0000-0003-3285-0168 2021 , 'Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net' , Brain structure & Function , doi: 10.1007/s00429-021-02327-3.

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Abstract

The calcium binding protein parvalbumin is expressed in interneurons of two main morphologies, the basket and chandelier cells, which target perisomatic domains on principal cells and are extensively interconnected in laminar networks by synapses and gap junctions. Beyond its utility as a convenient cellular marker, parvalbumin is an unambiguous identifier of the key role that these interneurons play in the fundamental functions of the cortex. They provide a temporal framework for principal cell activity by propagating gamma oscillation, providing coherence for cortical information processing and the basis for timing-dependent plasticity processes. As these parvalbumin networks mature, they are physically and functionally stabilised by axonal myelination and development of the extracellular matrix structure termed the perineuronal net. This maturation correlates with the emergence of high-speed, highly energetic activity and provides a coherent foundation for the unique ability of the cortex to cross-correlate activity across sensory modes and internal representations.

Item Type: Article
Authors/Creators:Bucher, EA and Collins, JM and King, AE and Vickers, JC and Kirkcaldie, MTK
Keywords: cortex, interneuron, parvalbumin, perineuronal nets, myelin
Journal or Publication Title: Brain structure & Function
Publisher: Springer-Verlag
ISSN: 1863-2653
DOI / ID Number: 10.1007/s00429-021-02327-3
Copyright Information:

© Crown 2021

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