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There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF)

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Nambiar, S, Clynick, B, How, BS, King, A, Walters, EH ORCID: 0000-0002-0993-4374, Goh, NS, Corte, TJ, Trengove, R, Tan, D and Moodley, Y 2021 , 'There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF)' , Respiratory Research, vol. 22, no. 1 , pp. 1-8 , doi: 10.1186/s12931-021-01682-3.

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Abstract

Background:Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). However, its potential role in IPF pathogenesis remains unclear.Methods:In this study, we used ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to characterize lipid changes in plasma derived from IPF patients with stable and progressive disease. We further applied a data-independent acquisition (DIA) technique called SONAR, to improve the specificity of lipid identification.Results:Statistical modelling showed variable discrimination between the stable and progressive subjects, revealing differences in the detection of triglycerides (TG) and phosphatidylcholines (PC) between progressors and stable IPF groups, which was further confirmed by mass spectrometry imaging (MSI) in IPF tissue.Conclusion:This is the first study to characterise lipid metabolism between stable and progressive IPF, with results suggesting disparities in the circulating lipidome with disease progression.

Item Type: Article
Authors/Creators:Nambiar, S and Clynick, B and How, BS and King, A and Walters, EH and Goh, NS and Corte, TJ and Trengove, R and Tan, D and Moodley, Y
Journal or Publication Title: Respiratory Research
Publisher: BioMed Central Ltd.
ISSN: 1465-9921
DOI / ID Number: 10.1186/s12931-021-01682-3
Copyright Information:

© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

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