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Revisiting mitochondria scored cancer progression and metastasis


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Gundamaraju, R, LU, W ORCID: 0000-0003-1550-2276 and Manikam, R 2021 , 'Revisiting mitochondria scored cancer progression and metastasis' , Cancers, vol. 13, no. 3 , pp. 1-13 , doi: 10.3390/cancers13030432.

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The Warburg effect has immensely succored the study of cancer biology, especially in highlighting the role of mitochondria in cancer stemness and their benefaction to the malignancy of oxidative and glycolytic cancer cells. Mitochondrial genetics have represented a focal point in cancer therapeutics due to the involvement of mitochondria in programmed cell death. The mitochondrion has been well established as a switch in cell death decisions. The mitochondrion's instrumental role in central bioenergetics, calcium homeostasis, and translational regulation has earned it its fame in metastatic dissemination in cancer cells. Here, we revisit and review mechanisms through which mitochondria influence oncogenesis and metastasis by underscoring the oncogenic mitochondrion that is capable of transferring malignant capacities to recipient cells.

Item Type: Article
Authors/Creators:Gundamaraju, R and LU, W and Manikam, R
Keywords: OXPHOS, Warburg effect, cancer, cancer therapeutics, metastasis, mitochondria
Journal or Publication Title: Cancers
Publisher: MDPI
ISSN: 2072-6694
DOI / ID Number: 10.3390/cancers13030432
Copyright Information:

Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (

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