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The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer's disease

Pan, G, King, A ORCID: 0000-0003-1792-0965, Wu, F ORCID: 0000-0003-3753-974X, Simpson-Yap, S ORCID: 0000-0001-6521-3056, Woodhouse, A ORCID: 0000-0002-4246-7624, Phipps, A and Vickers, JC ORCID: 0000-0001-5671-4879 2021 , 'The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer's disease' , Ageing Research Reviews, vol. 70 , pp. 1-15 , doi: 10.1016/j.arr.2021.101402.

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Alzheimer's disease (AD) is a complex neurological disorder of uncertain aetiology, although substantial research has been conducted to explore important factors related to risk of onset and progression. Both lifestyle (e.g., complex mental stimulation, vascular health) and genetic factors (e.g., APOE, BDNF, PICALM, CLU, APP, PSEN1, PSEN2, and other genes) have been associated with AD risk. Despite more than thirty years of genetic research, much of the heritability of AD is not explained by measured loci. This suggests that the missing heritability of AD might be potentially related to rare variants, gene-environment and gene-gene interactions, and potentially epigenetic modulators. Moreover, while ageing is the most substantial factor risk for AD, there are limited longitudinal studies examining the association of genetic factors with decline in cognitive function due to ageing and the preclinical stages of this condition. This review summarises findings from currently available research on the genetic factors of ageing-related cognitive change and AD and suggests some future research directions.

Item Type: Article
Authors/Creators:Pan, G and King, A and Wu, F and Simpson-Yap, S and Woodhouse, A and Phipps, A and Vickers, JC
Keywords: APOE, Alzheimer's disease, cognitive decline, cognitive function, genetics, PRS. polygenic risk score
Journal or Publication Title: Ageing Research Reviews
Publisher: Elsevier Science
ISSN: 1568-1637
DOI / ID Number: 10.1016/j.arr.2021.101402
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© 2021 Published by Elsevier B.V.

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