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A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

Ahmadi, S, Wang, S, Nagpal, R, Wang, B, Jain, S, Razazan, A, Mishra, SP, Zhu, X, Wang, Z, Kavanagh, K and Yadav, H 2020 , 'A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis' , JCI Insight, vol. 5, no. 9 , pp. 1-18 , doi: 10.1172/jci.insight.132055.

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Abstract

Inflammation is a major risk factor of morbidity and mortality in older adults. Although its precise etiology is unknown, low-grade inflammation in older adults is commonly associated with increased intestinal epithelial permeability (leaky gut) and abnormal (dysbiotic) gut microbiota. The increasing older population and lack of treatments to reduce aging-related microbiota dysbiosis, leaky gut, and inflammation culminates in a rise in aging-related comorbidities, constituting a significant public health concern. Here, we demonstrate that a human-origin probiotic cocktail containing 5 Lactobacillus and 5 Enterococcus strains isolated from healthy infant gut prevented high-fat diet–induced (HFD-induced) microbiota dysbiosis, leaky gut, inflammation, metabolic dysfunctions, and physical function decline in older mice. Probiotic-modulated gut microbiota primarily reduced leaky gut by increasing tight junctions, which in turn reduced inflammation. Mechanistically, probiotics modulated microbiota in a way to increase bile salt hydrolase activity, which in turn increased taurine abundance in the gut that stimulated tight junctions and suppressed gut leakiness. Furthermore, in Caenorhabditis elegans, taurine increased life span, reduced adiposity and leaky gut, and enhanced physical function. The results suggest that such probiotic therapies could prevent or treat aging-related leaky gut and inflammation in the elderly.

Item Type: Article
Authors/Creators:Ahmadi, S and Wang, S and Nagpal, R and Wang, B and Jain, S and Razazan, A and Mishra, SP and Zhu, X and Wang, Z and Kavanagh, K and Yadav, H
Keywords: gastroenterology, glucose metabolism, innate immunity, macrophages, microbiology
Journal or Publication Title: JCI Insight
Publisher: American Society for Clinical Investigation
ISSN: 2379-3708
DOI / ID Number: 10.1172/jci.insight.132055
Copyright Information:

Copyright 2020 American Societyfor Clinical Investigation

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