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Outcome measures for technique survival reported in peritoneal dialysis: A systematic review

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Elphick, E, Holmes, M, Tabinor, M, Cho, Y, Nguyen, T, Harris, T, Wang, AYM, Jain, AK, Ponce, D, Chow, JSF, Nadeau-Fredette, AC, Liew, A, Boudville, N, Tong, A, Johnson, DW, Davies, SJ, Perl, J, Manera, KE and Lambie, M 2021 , 'Outcome measures for technique survival reported in peritoneal dialysis: A systematic review' , Peritoneal Dialysis International , pp. 1-9 , doi: 10.1177/0896860821989874.

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Abstract

Background: Peritoneal dialysis (PD) technique survival is an important outcome for patients, caregivers and health professionals, however, the definition and measures used for technique survival vary. We aimed to assess the scope and consistency of definitions and measures used for technique survival in studies of patients receiving PD.Method: MEDLINE, EMBASE and CENTRAL databases were searched for randomised controlled studies (RCTs) conducted in patients receiving PD reporting technique survival as an outcome between database inception and December 2019. The definition and measures used were extracted and independently assessed by two reviewers.Results: We included 25 RCTs with a total of 3645 participants (41-371 per trial) and follow up ranging from 6 weeks to 4 years. Terminology used included 'technique survival' (10 studies), 'transfer to haemodialysis (HD)' (8 studies) and 'technique failure' (7 studies) with 17 different definitions. In seven studies, it was unclear whether the definition included transfer to HD, death or transplantation and eight studies reported 'transfer to HD' without further definition regarding duration or other events. Of those remaining, five studies included death in their definition of a technique event, whereas death was censored in the other five. The duration of HD necessary to qualify as an event was reported in only four (16%) studies. Of the 14 studies reporting causes of an event, all used a different list of causes.Conclusion: There is substantial heterogeneity in how PD technique survival is defined and measured, likely contributing to considerable variability in reported rates. Standardised measures for reporting technique survival in PD studies are required to improve comparability.

Item Type: Article
Authors/Creators:Elphick, E and Holmes, M and Tabinor, M and Cho, Y and Nguyen, T and Harris, T and Wang, AYM and Jain, AK and Ponce, D and Chow, JSF and Nadeau-Fredette, AC and Liew, A and Boudville, N and Tong, A and Johnson, DW and Davies, SJ and Perl, J and Manera, KE and Lambie, M
Keywords: peritoneal dialysis, systematic review, technique survival, transfer to haemodialysis
Journal or Publication Title: Peritoneal Dialysis International
Publisher: SAGE Publications
ISSN: 0896-8608
DOI / ID Number: 10.1177/0896860821989874
Copyright Information:

Copyright The Author(s) 2021. This is an open access article made available under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/)

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