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Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones


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Kannangara, JR, Mirth, CK and Warr, CG ORCID: 0000-0002-5289-3950 2021 , 'Regulation of ecdysone production in Drosophila by neuropeptides and peptide hormones' , Open Biology, vol. 11, no. 2 , pp. 1-11 , doi: 10.1098/rsob.200373.

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In both mammals and insects, steroid hormones play a major role indirecting the animal’s progression through developmental stages. To maximize fitness outcomes, steroid hormone production is regulated by theenvironmental conditions experienced by the animal. In insects, the steroidhormone ecdysone mediates transitions between developmental stages andis regulated in response to environmental factors such as nutrition. Theseenvironmental signals are communicated to the ecdysone-producing glandvia the action of neuropeptide and peptide hormone signalling pathways.While some of these pathways have been well characterized, there is evidence to suggest more signalling pathways than has previously beenthought function to control ecdysone production, potentially in responseto a greater range of environmental conditions. Here, we review the neuropeptide and peptide hormone signalling pathways known to regulate theproduction of ecdysone in the model genetic insect Drosophila melanogaster,as well as what is known regarding the environmental signals that triggerthese pathways. Areas for future research are highlighted that can furthercontribute to our overall understanding of the complex orchestration ofenvironmental, physiological and developmental cues that together producea functioning adult organism.

Item Type: Article
Authors/Creators:Kannangara, JR and Mirth, CK and Warr, CG
Keywords: Drosophila melanogaster, development, ecdysone, growth, neuropeptides, signalling
Journal or Publication Title: Open Biology
Publisher: Royal Society Pub.
ISSN: 2046-2441
DOI / ID Number: 10.1098/rsob.200373
Copyright Information:

© 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License,, which permits unrestricted use, provided the original author and source are credited.

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