Open Access Repository

Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers

Zhou, J, Zhang, H, Zou, D, Zhou, Z ORCID: 0000-0002-0835-8686, Wang, W, Luo, Y and Liu, T 2021 , 'Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers' , Expert Review of Molecular Diagnostics, vol. 21, no. 10 , pp. 1095-1104 , doi: 10.1080/14737159.2021.1964959.

Full text not available from this repository.

Abstract

Objective: To explore the clinicopathologic and prognostic significance of circular RNA plasmacytoma variant translocation 1 (circPVT1) in various cancers.Methods: Several databases were searched for eligible studies published before March 01, 2021. The pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to assess the association between circPVT1 expression and prognostic outcomes of tumor including age, gender, clinical stage, tumor size, metastasis and overall survival. Begg's funnel plots and Egger's test were used to evaluate the publication bias. The robustness of our results was assessed using sensitivity analysis.Results: Ten studies comprising a total of 878 patients with cancer were included in this meta-analysis. The results showed that the high expression of circPVT1 was significantly related to clinical stage (OR=3.44, 95% CI: 2.40-4.94, PConclusions: High expression of circPVT1 may predict an advanced clinical stage and poor prognosis of tumor, suggesting that circPVT1 may serve as a potential prognostic marker in cancers.

Item Type: Article
Authors/Creators:Zhou, J and Zhang, H and Zou, D and Zhou, Z and Wang, W and Luo, Y and Liu, T
Keywords: CircPVT1, cancers, clinical features, prognosis, meta-analysis
Journal or Publication Title: Expert Review of Molecular Diagnostics
Publisher: Taylor & Francis
ISSN: 1473-7159
DOI / ID Number: 10.1080/14737159.2021.1964959
Copyright Information:

Copyright 2021 Informa UK Limited, trading as Taylor & Francis Group

Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP