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Effect of insulin-induced lipodystrophy on glycemic control among children and adolescents with diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

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Tsadik, AG, Atey, TM, Nedi, T, Fantahun, B and Feyissa, M 2018 , 'Effect of insulin-induced lipodystrophy on glycemic control among children and adolescents with diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia' , Journal of Diabetes Research , pp. 1-7 , doi: 10.1155/2018/4910962.

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Abstract

Background: Lipodystrophy is one of the clinical complications of insulin injection that affects insulin absorption and leads to poor glycemic control.Objective: To assess insulin-induced lipodystrophy and glycemic control.Methods: A cross sectional study was done on 176 diabetic children and adolescents who inject insulin for a minimum of one year. First, anthropometric and clinical characteristics of the patients were recorded in questionnaire, and then observation and palpation techniques were used in assessing lipodystrophy.Result: Out of the total 176 participants, 103 (58.5%) had insulin-induced lipodystrophy, of them 100 (97.1%) had lipohypertrophy and 3 (2.9%) had lipoatrophy. Being younger, failure to rotate the injection site every week and multiple reuse of insulin syringe had significant influence in development of insulin-induced lipohypertrophy. Lipohypertrophy in turn was associated with the use of higher dose of insulin and nonoptimal glycemic control.Conclusion: Findings of this study revealed that in spite of using recombinant human insulin, the magnitude of the lipohypertrophy still remained high. Therefore, a routine workup of insulin-injecting patients for such complication is necessary, especially in the individuals who have a nonoptimal glycemic control.

Item Type: Article
Authors/Creators:Tsadik, AG and Atey, TM and Nedi, T and Fantahun, B and Feyissa, M
Keywords: pharmacy, clinical pharmacy, pharmacy practice
Journal or Publication Title: Journal of Diabetes Research
Publisher: Hindawi Limited
ISSN: 2314-6753
DOI / ID Number: 10.1155/2018/4910962
Copyright Information:

Copyright 2018 Afewerki Gebremeskel Tsadik et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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