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Emerging advances of nanotechnology in drug and vaccine delivery against viral associated respiratory infectious diseases (VARID)

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Seyfoori, A, Barough, MS, Mokarram, P, Ahmadi, M, Mehrbod, P, Sheidary, A, Madrakian, T, Kiumarsi, M, Walsh, T, McAlinden, KD, Ghosh, CC, Sharma, P, Zeki, AA, Ghavami, S and Akbari, M 2021 , 'Emerging advances of nanotechnology in drug and vaccine delivery against viral associated respiratory infectious diseases (VARID)' , International Journal of Molecular Sciences, vol. 22, no. 13 , pp. 1-31 , doi: 10.3390/ijms22136937.

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Abstract

Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI). VRIs are proceeded by an infection caused by viruses infecting the respiratory system. For the past 100 years, viral associated respiratory epidemics have been the most common cause of infectious disease worldwide. Due to several drawbacks of the current anti-viral treatments, such as drug resistance generation and non-targeting of viral proteins, the development of novel nanotherapeutic or nano-vaccine strategies can be considered essential. Due to their specific physical and biological properties, nanoparticles hold promising opportunities for both anti-viral treatments and vaccines against viral infections. Besides the specific physiological properties of the respiratory system, there is a significant demand for utilizing nano-designs in the production of vaccines or antiviral agents for airway-localized administration. SARS-CoV-2, as an immediate example of respiratory viruses, is an enveloped, positive-sense, single-stranded RNA virus belonging to the coronaviridae family. COVID-19 can lead to acute respiratory distress syndrome, similarly to other members of the coronaviridae. Hence, reviewing the current and past emerging nanotechnology-based medications on similar respiratory viral diseases can identify pathways towards generating novel SARS-CoV-2 nanotherapeutics and/or nano-vaccines.

Item Type: Article
Authors/Creators:Seyfoori, A and Barough, MS and Mokarram, P and Ahmadi, M and Mehrbod, P and Sheidary, A and Madrakian, T and Kiumarsi, M and Walsh, T and McAlinden, KD and Ghosh, CC and Sharma, P and Zeki, AA and Ghavami, S and Akbari, M
Keywords: COVID-19, SARS-CoV-2, nano-vaccine, nanomedicine, respiratory disease, viral infection
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: MDPI
ISSN: 1661-6596
DOI / ID Number: 10.3390/ijms22136937
Copyright Information:

Copyright 2021 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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