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Cognitive deficits in Parkinson’s disease: current perspectives

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Cosgrove, J and Alty, JE ORCID: 0000-0002-5456-8676 2018 , 'Cognitive deficits in Parkinson’s disease: current perspectives' , Journal of Parkinsonism and Restless Legs Syndrome, vol. 8 , 1–11 , doi: 10.2147/JPRLS.S125064.

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Abstract

Cognitive dysfunction is a common and significant non-motor symptom of Parkinson’sdisease (PD). PD mild cognitive impairment (PD-MCI) is evident in approximatelyone-quarter of patients at the time of PD diagnosis, and half of PD patients have progressed toPD dementia (PDD) after 10 years. The transition to PDD from PD-MCI is not linear and maydepend on the facets of cognition affected. Despite increased understanding of pathological,neurotransmitter and genetic drivers, there are no proven pharmacological treatments for PDMCIand those licensed for PDD are of modest benefit only. Biomarkers to predict those mostat risk of developing PDD are under investigation and are likely to be essential so that early andindividualized treatment can be provided.

Item Type: Article
Authors/Creators:Cosgrove, J and Alty, JE
Keywords: parkinson's disease, dementia, mild cognitive impairment
Journal or Publication Title: Journal of Parkinsonism and Restless Legs Syndrome
Publisher: Dove Medical Press Ltd.(DovePress)
ISSN: 1927-7725
DOI / ID Number: 10.2147/JPRLS.S125064
Copyright Information:

Copyright 2018 Cosgrove and Alty. Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) https://creativecommons.org/licenses/by-nc/3.0/

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