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Major histocompatibility polymorphism associated with resistance towards amoebic gill disease in Atlantic salmon (Salmo salar L.)


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Wynne, JW, Cook, MT, Nowak, BF and Elliott, NG 2007 , 'Major histocompatibility polymorphism associated with resistance towards amoebic gill disease in Atlantic salmon (Salmo salar L.)' , Fish and Shellfish Immunology, vol. 22, no. 6 , 707- 717 , doi: 10.1016/j.fsi.2006.08.019.

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The association between major histocompatibility (MH) polymorphism and the severity of infection by amoebic gill disease
(AGD) was investigated across 30 full sibling families of Atlantic salmon. Individuals were challenged with AGD for 19 days
and then their severity of infection scored by histopathological examination of the gills. Fish were then genotyped for the MH class
I (Sasa-UBA) and MH class II alpha (Sasa-DAA) genes using polymorphic repeats embedded within the 30 untranslated regions of
the Sasa-UBA and Sasa-DAA genes. High variation in the severity of infection was observed across the sample material, ranging
from 0% to 85% gill filaments infected. In total, seven Sasa-DAA-3UTR and ten Sasa-UBA-3UTR marker alleles were identified
across the 30 families. A significant association between the marker allele Sasa-DAA-3UTR 239 and a reduction in AGD severity
was detected. There was also a significant association found between AGD severity and the presence of two Sasa-DAA-3UTR
genotypes. While the associations between MH allele/genotypes and AGD severity reported herein may be statistically significant,
the small sample sizes observed for some alleles and genotypes means these associations should be considered as suggestive and
future research is required to verify their biological significance.

Item Type: Article
Authors/Creators:Wynne, JW and Cook, MT and Nowak, BF and Elliott, NG
Keywords: Salmo salar; Major histocompatibility complex; Amoebic gill disease; Disease resistance
Journal or Publication Title: Fish and Shellfish Immunology
Publisher: Academic Press
ISSN: 1050-4648
DOI / ID Number: 10.1016/j.fsi.2006.08.019
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