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Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms

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Zheng, S, Tu, L, Cicuttini, F, Zhu, Z, Han, W, Antony, B ORCID: 0000-0001-8704-6084, Wluka, AE, Winzenberg, T ORCID: 0000-0002-4112-3491, Aitken, D ORCID: 0000-0001-5685-7634, Blizzard, L ORCID: 0000-0002-9541-6943, Jones, G ORCID: 0000-0002-9814-0006 and Ding, C ORCID: 0000-0002-9479-730X 2021 , 'Depression in patients with knee osteoarthritis: risk factors and associations with joint symptoms' , BMC Musculoskeletal Disorders, vol. 22, no. 1 , pp. 1-10 , doi: 10.1186/s12891-020-03875-1.

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Abstract

Background: To describe demographic and clinical factors associated with the presence and incidence ofdepression and explore the temporal relationship between depression and joint symptoms in patients withsymptomatic knee osteoarthritis (OA).Methods: Three hundred ninety-seven participants were selected from a randomized controlled trial in people withsymptomatic knee OA and vitamin D deficiency (age 63.3 ± 7.1 year, 48.6% female). Depression severity and kneejoint symptoms were assessed using the patient health questionnaire (PHQ-9) and the Western Ontario andMcMaster Universities Osteoarthritis Index (WOMAC), respectively, at baseline and 24 months.Results: The presence and incidence of depression was 25.4 and 11.2%, respectively. At baseline, having youngerage, a higher body mass index (BMI), greater scores of WOMAC pain (PR: 1.05, 95%CI:1.03, 1.07), dysfunction (PR:1.02, 95%CI:1.01, 1.02) and stiffness (PR: 1.05, 95%CI: 1.02, 1.09), lower education level, having more than onecomorbidity and having two or more painful body sites were significantly associated with a higher presence ofdepression. Over 24 months, being female, having a higher WOMAC pain (RR: 1.05, 95%CI: 1.02, 1.09) anddysfunction score (RR: 1.02, 95%CI: 1.01, 1.03) at baseline and having two or more painful sites were significantlyassociated with a higher incidence of depression. In contrast, baseline depression was not associated with changesin knee joint symptoms over 24 months.Conclusion: Knee OA risk factors and joint symptoms, along with co-existing multi-site pain are associated with thepresence and development of depression. This suggests that managing common OA risk factors and jointsymptoms may be important for prevention and treatment depression in patients with knee OA.

Item Type: Article
Authors/Creators:Zheng, S and Tu, L and Cicuttini, F and Zhu, Z and Han, W and Antony, B and Wluka, AE and Winzenberg, T and Aitken, D and Blizzard, L and Jones, G and Ding, C
Keywords: depression, joint symptoms, knee osteoarthritis, risk factors
Journal or Publication Title: BMC Musculoskeletal Disorders
Publisher: Biomed Central Ltd
ISSN: 1471-2474
DOI / ID Number: 10.1186/s12891-020-03875-1
Copyright Information:

© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License, (https://creativecommons.org/licenses/by/4.0/) which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

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