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Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults: analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)

Talevski, J, Sanders, KM, Watts, JJ, Nicholson, GC, Seeman, E, Iuliano, S, Prince, R, March, L, Winzenberg, T ORCID: 0000-0002-4112-3491, Duque, G, Ebeling, PR, Borgstrom, F, Kanis, JA, Stuart, AL, Beauchamp, A and Brennan-Olsen, SL 2021 , 'Sex differences in recovery of quality of life 12 months post-fracture in community-dwelling older adults: analyses of the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS)' , Osteoporosis International , doi: 10.1007/s00198-021-06058-3.

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Abstract

In this study of 695 Australian older adults (aged ≥50 years), we found that men and women had a similar trajectory of health-related quality of life (HRQoL) recovery following fragility fracture at any skeletal site. These results provide us with critical knowledge that improves our understanding of health outcomes post-fracture.Introduction: Mortality is higher in men than that in women following a fragility fracture, but it is unclear whether recovery of patient-reported outcomes such as health-related quality of life (HRQoL) differs between sexes. This study aimed to identify sex differences in HRQoL recovery 12 months post-fracture.Methods: Data were from the Australian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study (AusICUROS). Participants recruited to AusICUROS were adults aged ≥50 years who sustained a fragility fracture. HRQoL was measured using the EQ-5D-3L at three time-points post-fracture: within 2 weeks (including pre-fracture recall) and at 4 and 12 months. Multivariate logistic regression analyses were undertaken, adjusting for confounders including age, education, income, and healthcare utilization post-fracture.Results: Overall, 695 AusICUROS participants (536 women, 77.1%) were eligible for analysis with fractures at the hip (n = 150), distal forearm (n = 261), vertebrae (n = 61), humerus (n = 52), and other skeletal sites (n = 171). At the time of fracture, men were younger, reported a higher income, and were more likely to be employed, compared with women. For all fracture sites combined, there were no differences between men and women in recovery to pre-fracture HRQoL at 12-month follow-up (adjusted OR = 1.09; 95% CI: 0.75-1.61). When stratified by fracture site, no significant sex differences were seen for hip (OR = 1.02; 95% CI: 0.42-2.52), distal forearm (OR = 1.60; 95% CI: 0.68-3.78), vertebral (OR = 2.28; 95% CI: 0.61-8.48), humeral (OR = 1.62; 95% CI: 0.16-9.99), and other fractures (OR = 1.00; 95% CI: 0.44-2.26).Conclusion: Community-dwelling men and women who survived the 12 months following fragility fracture had a similar trajectory of HRQoL recovery at any skeletal site.

Item Type: Article
Authors/Creators:Talevski, J and Sanders, KM and Watts, JJ and Nicholson, GC and Seeman, E and Iuliano, S and Prince, R and March, L and Winzenberg, T and Duque, G and Ebeling, PR and Borgstrom, F and Kanis, JA and Stuart, AL and Beauchamp, A and Brennan-Olsen, SL
Keywords: aging, fractures, osteoporosis, quality of life, sex
Journal or Publication Title: Osteoporosis International
Publisher: Springer International
ISSN: 0937-941X
DOI / ID Number: 10.1007/s00198-021-06058-3
Copyright Information:

Copyright 2021 International Osteoporosis Foundation and National Osteoporosis Foundation

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