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Experimental challenge models and in vitro models to investigate efficacy of treatments and vaccines against Amoebic Gill Disease

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Hudson, J and Nowak, BF ORCID: 0000-0002-0347-643X 2021 , 'Experimental challenge models and in vitro models to investigate efficacy of treatments and vaccines against Amoebic Gill Disease' , Microorganisms, vol. 9, no. 4 , pp. 1-11 , doi: 10.3390/microorganisms9040710.

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Abstract

Amoebic Gill Disease (AGD) severely affects salmonid mariculture due to fish losses and costs associated with management of the disease. Continued research into management solutions, including new treatments and vaccine development, is highly important for the future of salmonid production worldwide. This requires both in vitro (both pathogen only and host-pathogen models) and in vivo (disease challenge) testing. Challenge models are still widely varied, in particular with regard to: infection methods (cohabitation or immersion), source of the pathogen (isolated from infected fish or cultured), infectious dose, environmental conditions (in particular temperature) and the endpoints across experimental treatment and vaccine studies which makes comparisons between studies difficult. This review summarises in vitro assays, the challenge methods and endpoints used in studies of experimental treatments and vaccines for AGD.

Item Type: Article
Authors/Creators:Hudson, J and Nowak, BF
Keywords: Amoebic Gill Disease, experimental infection, in vivo, in vitro, efficacy, Neoparamoeba perurans, vaccine testing, treatment testing
Journal or Publication Title: Microorganisms
Publisher: MDPIAG
ISSN: 2076-2607
DOI / ID Number: 10.3390/microorganisms9040710
Copyright Information:

Copyright 2021 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

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