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Myelin Protein Zero180–199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice

Gonsalvez, DG, Yoo, SW, Craig, GA, Wood, RJ, Fletcher, JL ORCID: 0000-0003-2009-0798, Murray, SS and Xiao, J 2018 , 'Myelin Protein Zero180–199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice', in A Woodhoo (ed.), Myelin , Humana Press, United States, pp. 243-250.

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Abstract

Mouse models of peripheral demyelinating neuropathy play an important role in enabling the study ofdisease pathogenesis. Further, induction in transgenic mice allows for the precise interrogation of diseasemechanisms, as well as the analysis of the efficacy and mechanisms of potential new therapies. Here wedescribe a method to successfully induce experimental autoimmune neuritis (EAN) using myelin proteinzero (P0)180–199 peptide in combination with Freund’s complete adjuvant and pertussis toxin in theC57BL/6 mouse strain. We also outline a sensitive paradigm of accurately assessing the extent of functionaldeficits occurring in murine EAN.

Item Type: Book Section
Authors/Creators:Gonsalvez, DG and Yoo, SW and Craig, GA and Wood, RJ and Fletcher, JL and Murray, SS and Xiao, J
Keywords: peripheral nervous system, demyelinating disease, animal model, Experimental autoimmune neuritis, myelin, P0, peripheral neuropathy, C57BL/6 mice
Publisher: Humana Press
Copyright Information:

Copyright 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018

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