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Abstract

Central nervous system injury, specifically traumatic brain and spinal cord injury, can have significant long lasting effects. There are no comprehensive treatments to combat the injury and sequalae of events that occurring following a central nervous system trauma. Herein we discuss the potential for the epothilone family of microtubule stabilizing agents to improve outcomes following experimentally induced trauma. These drugs, which are able to cross the blood-brain barrier, may hold great promise for the treatment of central nervous system trauma and the current literature presents the extensive range of beneficial effects these drugs may have following trauma in animal models. Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. Therefore, we present a case for a greater emphasis to be placed upon age when using an intervention aimed at neural regeneration and highlight the importance of tailoring the therapeutic regime in the clinic to the age of the patient to promote improved patient outcomes.

Item Type:	Article
Authors/Creators:	Clark, J and Zhu, Zhendan and Chuckowree, J and Dickson, T and Blizzard, C
Keywords:	aging, epothilones, glial, microtubule stablization, neuron, neuronal regeneration, spinal cord injury, traumatic brain injury
Journal or Publication Title:	Neural Regeneration Research
Publisher:	Wolters Kluwer Health
ISSN:	1673-5374
DOI / ID Number:	10.4103/1673-5374.295312
Copyright Information:	Copyright © 2021, Wolters Kluwer Medknow Publications. This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, (https://creativecommons.org/licenses/by-nc-sa/4.0/) which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Related URLs:	UTAS Profile: Chuckowree, J Google Scholar: Dickson, T UTAS Profile: Dickson, T UTAS Profile: Blizzard, C
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