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Signal intensity alteration and maximal area of pericruciate fat pad are associated with incident radiographic osteoarthritis: data from the Osteoarthritis Initiative

Li, Y, Li, J, Zhu, Z, Cao, P, Han, W, Ruan, G, Fan, T, Hunter, DJ and Ding, C ORCID: 0000-0002-9479-730X 2021 , 'Signal intensity alteration and maximal area of pericruciate fat pad are associated with incident radiographic osteoarthritis: data from the Osteoarthritis Initiative' , European Radiology , doi: 10.1007/s00330-021-08193-1.

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Abstract

Objective: To determine whether pericruciate fat pad (PCFP) signal intensity alteration and maximal area are associated with incident radiographic osteoarthritis (ROA) over 4 years in the Osteoarthritis Initiative (OAI) study.Methods: Participants were from the Osteoarthritis Initiative (OAI) study. Case knees (n = 355) were defined by incident ROA between 12 and 48 months visits and were matched by sex, age, and radiographic status with control knees (n = 355). Magnetic resonance images (MRIs) were used to assess PCFP signal intensity alteration and PCFP maximal area at P0 (time of onset of ROA), P-1 (1 year prior to P0), and baseline. Conditional logistic regression analyses were applied to assess associations between PCFP measures and the risk of incident ROA.Results: The mean age of participants was 60.1 years and 66.9% were women. In multivariable analyses, PCFP signal intensity alteration measured at three time points (OR [95%CI]: 1.28 [1.10-1.50], 1.52 [1.30-1.78], 1.50 [1.27-1.76], respectively) and PCFP maximal area (OR [95%CI]: 1.21 [1.03-1.42], 1.27 [1.07-1.52], 1.37 [1.15-1.62], respectively) were significantly associated with incident ROA.Conclusions: PCFP signal intensity alteration and maximal area were associated with incident ROA over 4 years, implying that they may have roles to play in ROA.

Item Type: Article
Authors/Creators:Li, Y and Li, J and Zhu, Z and Cao, P and Han, W and Ruan, G and Fan, T and Hunter, DJ and Ding, C
Keywords: adipose tissue, magnetic resonance imaging, osteoarthritis, knee
Journal or Publication Title: European Radiology
Publisher: Springer-Verlag
ISSN: 0938-7994
DOI / ID Number: 10.1007/s00330-021-08193-1
Copyright Information:

Copyright European Society of Radiology 2021

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