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The effect of automated oxygen control on clinical outcomes in preterm infants: a pre- and post-implementation cohort study

Salverda, HH, Oldenburger, NJ, Rijken, M, Pauws, SC, Dargaville, PA and Te Pas, AB 2021 , 'The effect of automated oxygen control on clinical outcomes in preterm infants: a pre- and post-implementation cohort study' , European Journal of Pediatrics, vol. 180, no. 7 , 2107–2113 , doi: 10.1007/s00431-021-03982-8.

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Abstract

Several studies demonstrated an increase in time spent within target range when automated oxygen control (AOC) is used.However the effect on clinical outcome remains unclear. We compared clinical outcomes of preterm infants born before and afterimplementation of AOC as standard of care. In a retrospective pre-post implementation cohort study of outcomes for infants of24–29 weeks gestational age receiving respiratory support before (2012–2015) and after (2015–2018) implementation of AOC asstandard of care were compared. Outcomes of interest were mortality and complications of prematurity, number of ventilationdays, and length of stay in the Neonatal Intensive Care Unit (NICU). A total of 588 infants were included (293 pre- vs 295 in thepost-implementation cohort), with similar gestational age (27.8 weeks pre- vs 27.6 weeks post-implementation), birth weight(1033 grams vs 1035 grams) and other baseline characteristics. Mortality and rate of prematurity complications were not differentbetween the groups. Length of stay in NICU was not different, but duration of invasive ventilation was shorter in infants whoreceived AOC (6.4 ± 10.1 vs 4.7 ± 8.3, p = 0.029).Conclusion: In this pre-post comparison, the implementation of AOC did not lead to a change in mortality or morbidity duringadmission.

Item Type: Article
Authors/Creators:Salverda, HH and Oldenburger, NJ and Rijken, M and Pauws, SC and Dargaville, PA and Te Pas, AB
Keywords: hypoxemia, hyperoxia, closed loop, algorithm, neonate, respiratory
Journal or Publication Title: European Journal of Pediatrics
Publisher: Springer Verlag
ISSN: 0340-6199
DOI / ID Number: 10.1007/s00431-021-03982-8
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Copyright The Author(s) 2021

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