Open Access Repository

Antihypertensive drug class in combination with lipid lowering treatment for primary prevention of cardiovascular disease in the elderly

Zhou, Z ORCID: 0000-0002-0835-8686, Chowdhury, EK, Breslin, M ORCID: 0000-0002-8135-3136, Curtis, AJ, Reid, CM and Nelson, M ORCID: 0000-0001-9941-7161 2021 , 'Antihypertensive drug class in combination with lipid lowering treatment for primary prevention of cardiovascular disease in the elderly' , Heart and Lung, vol. 51 , pp. 40-45 , doi: 10.1016/j.hrtlng.2021.09.005.

Full text not available from this repository.

Abstract

Background: Antihypertensives and lipid-lowering therapy (LLT) are often used concurrently.Objectives: To determine whether there was a difference in clinical outcomes when older patients with LLT wereprescribed angiotensin-converting-enzyme-inhibitors (ACE-Is) compared with diuretics.Methods: This analysis included 648 LLT older users free of cardiovascular disease (CVD) from a trial comparingACE-I versus diuretic-based therapy. Comparisons were made between LLT+ACE-I (n = 335) and LLT+diuretic groups (n = 313) using multivariable Cox proportional-hazard models. Primary endpoints were all-causeand CVD mortality (in-trial [4.1-year]+post-trial [6.9-year]) and secondary endpoints (in-trial) were the composite of all-cause mortality and first CVD events and its components, CVD mortality and incident diabetes.Results: There were no significant differences between the two groups for the primary endpoints over the in-trialplus post-trial follow-up, nor was there a difference for any secondary outcomes over the in-trial follow-up.Conclusions: The LLT+ACE-I and LLT+diuretic combinations showed similar effects in CVD-free older individuals. Randomised trials are needed to provide conclusive evidence.

Item Type: Article
Authors/Creators:Zhou, Z and Chowdhury, EK and Breslin, M and Curtis, AJ and Reid, CM and Nelson, M
Keywords: liplid-lowering, blood pressure, primary prevention, cardiovascular disease
Journal or Publication Title: Heart and Lung
Publisher: Mosby
ISSN: 0147-9563
DOI / ID Number: 10.1016/j.hrtlng.2021.09.005
Copyright Information:

© 2021 Elsevier Inc. All rights reserved.

Related URLs:
Item Statistics: View statistics for this item

Actions (login required)

Item Control Page Item Control Page
TOP