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Brain-derived neurotrophic factor in central nervous system myelination: A new mechanism to promote myelin plasticity and repair

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Fletcher, JL ORCID: 0000-0003-2009-0798, Murray, SS and Xiao, J 2018 , 'Brain-derived neurotrophic factor in central nervous system myelination: A new mechanism to promote myelin plasticity and repair' , International Journal of Molecular Sciences, vol. 19, no. 12 , pp. 1-16 , doi: 10.3390/ijms19124131.

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Abstract

Brain-derived neurotrophic factor (BDNF) plays vitally important roles in neural development and plasticity in both health and disease. Recent studies using mutant mice to selectively manipulate BDNF signalling in desired cell types, in combination with animal models of demyelinating disease, have demonstrated that BDNF not only potentiates normal central nervous system myelination in development but enhances recovery after myelin injury. However, the precise mechanisms by which BDNF enhances myelination in development and repair are unclear. Here, we review some of the recent progress made in understanding the influence BDNF exerts upon the myelinating process during development and after injury, and discuss the cellular and molecular mechanisms underlying its effects. In doing so, we raise new questions for future research.

Item Type: Article
Authors/Creators:Fletcher, JL and Murray, SS and Xiao, J
Keywords: oligodendrocyte, myelin, BDNF, multiple sclerosis, TrkB
Journal or Publication Title: International Journal of Molecular Sciences
Publisher: Molecular Diversity Preservation International
ISSN: 1422-0067
DOI / ID Number: 10.3390/ijms19124131
Copyright Information:

Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).

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