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Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis

Chen, Y, Cheng, X, Sun, C, Kim, NH, Kailas, S, Qureshi, F, Karadsheh, Z, Wu, Y, Hu, L, Zhou, Z ORCID: 0000-0002-0835-8686, Bhan, C, Kim, KY, Manem, R, Cheng, C and Zhou, Q 2021 , 'Is metformin use associated with a reduced risk of oesophageal cancer? A systematic review and meta-analysis' , Postgraduate Medical Journal , pp. 1-5 , doi: 10.1136/postgradmedj-2021-140432.

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Abstract

Objectives: Studies on the association between metformin use and the risk of oesophageal cancer (OC) have generated controversial findings. This updated meta-analysis was conducted to reassess the effects of metformin on OC.Methods: A comprehensive search strategy was conducted to select relevant studies from origination to February 2021. Heterogeneity was evaluated through the Q test and I2 statistics. HRs and 95% CIs were pooled through either random-effect or fixed-effect models. Meta-regression, subgroup analyses, sensitivity analysis and publication bias diagnosis were also performed.Results: Seven studies with 5 426 343 subjects were included. Metformin use was associated with reduced risk of OC (HR=0.69, 95% CI 0.54 to 0.87, pConclusion: Metformin is associated with a reduced risk of OC. More well-designed studies are still needed to further elaborate on these associations.

Item Type: Article
Authors/Creators:Chen, Y and Cheng, X and Sun, C and Kim, NH and Kailas, S and Qureshi, F and Karadsheh, Z and Wu, Y and Hu, L and Zhou, Z and Bhan, C and Kim, KY and Manem, R and Cheng, C and Zhou, Q
Keywords: metformin, oesophageal cancer, meta-analysis
Journal or Publication Title: Postgraduate Medical Journal
Publisher: B M J Publishing Group
ISSN: 0032-5473
DOI / ID Number: 10.1136/postgradmedj-2021-140432
Copyright Information:

© Author(s) (or their employer(s)) 2021.

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