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Abstract

Objective: To compare the effect of two different automated oxygen control devices on target range (TR) time and occurrence of hypoxaemic and hyperoxaemic episodes.Design: Randomised cross-over study.Setting: Tertiary level neonatal unit in the Netherlands.Patients: Preterm infants (n=15) born between 24+0 and 29+6 days of gestation, receiving invasive or non-invasive respiratory support with oxygen saturation (SpO2) TR of 91%-95%. Median gestational age 26 weeks and 4 days (IQR 25 weeks 3 days-27 weeks 6 days) and postnatal age 19 (IQR 17-24) days.Interventions: Inspired oxygen concentration was titrated by the OxyGenie controller (SLE6000 ventilator) and the CLiO2 controller (AVEA ventilator) for 24 hours each, in a random sequence, with the respiratory support mode kept constant.Main outcome measures: Time spent within set SpO2 TR (91%-95% with supplemental oxygen and 91%-100% without supplemental oxygen).Results: Time spent within the SpO2 TR was higher during OxyGenie control (80.2 (72.6-82.4)% vs 68.5 (56.7-79.3)%, p2 2 deviations occurred less frequently during OxyGenie control.Conclusions: The OxyGenie control algorithm was more effective in keeping the oxygen saturation within TR and preventing hyperoxaemia and equally effective in preventing hypoxaemia (SpO2

Item Type:	Article
Authors/Creators:	Salverda, HH and Cramer, SJE and Witlox, RSGM and Gale, TJ and Dargaville, PA and Pauws, SC and Te Pas, AB
Keywords:	neonatology, technology
Journal or Publication Title:	Archives of Disease in Childhood. Fetal and Neonatal Edition
Publisher:	British Medical Association
ISSN:	1359-2998
DOI / ID Number:	10.1136/archdischild-2020-321387
Copyright Information:	© Author(s) (or their employer(s)) 2021. Re-use permitted under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)license, (https://creativecommons.org/licenses/by-nc/4.0/). No commercial re-use. See rights and permissions. Published by BMJ.
Related URLs:	Google Scholar: Gale, TJ UTAS Profile: Gale, TJ UTAS Profile: Dargaville, PA
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