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Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated with Less BMD Loss over 10 Years

Thompson, M, Aitken, D ORCID: 0000-0001-5685-7634, Balogun, S ORCID: 0000-0001-6415-5536, Cicuttini, F and Jones, G ORCID: 0000-0002-9814-0006 2021 , 'Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated with Less BMD Loss over 10 Years' , Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 8 , E2995-E3004 , doi: 10.1210/clinem/dgab197.

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Abstract

Context:Vitamin D deficiency is a common, modifiable determinant of musculoskeletal health.Objective: There are limited data that examine the longitudinal change in population 25-hydroxyvitamin D (25[OH]D) and none that evaluate the long-term skeletal outcomes of longitudinal vitamin D status.Methods: A prospective cohort analysis was conducted of community-dwelling adults aged 50 to 80 years who had 25(OH)D assessed by radioimmunoassay and bone mineral density (BMD) by dual-energy x-ray absorptiometry at baseline (n= 1096), 2.5 (n= 870), and 10 (n = 565) years. Sun exposure was quantified by questionnaire and supplement use at clinic review. 25(OH)D less than 50 nmol/L was considered deficient. Participants were provided with their 25(OH)D results.Results: Over 10 years 25(OH)D increased (52.2 ± 17.0 to 63.5 ± 23.6 nmol/L, P P P P = .003) sun exposure, change in summer (β = 1.27, P = .002) and winter (β = 1.47, P P = .027), lumbar spine (β = 0.033, P = .003), and total hip (β = 0.023, P = .021) compared to persistent vitamin D deficiency. Achieving vitamin D sufficiency was associated with less BMD loss at the lumbar spine (β = 0.045, PConclusions: Population 25(OH)D concentration increased because of a combination of increased sun exposure and supplement use. Maintaining or achieving vitamin D sufficiency was associated with less BMD loss over 10 years.

Item Type: Article
Authors/Creators:Thompson, M and Aitken, D and Balogun, S and Cicuttini, F and Jones, G
Keywords: 25-hydroxyvitamin D, BMD, bone mineral density, vitamin D, vitamin D deficiency
Journal or Publication Title: Journal of Clinical Endocrinology and Metabolism
Publisher: Charles C. Thomas
ISSN: 0021-972X
DOI / ID Number: 10.1210/clinem/dgab197
Copyright Information:

© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.

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