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Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life

Meng, Y, Magnussen, CG ORCID: 0000-0002-6238-5730, Wu, F ORCID: 0000-0003-3753-974X, Buscot, M-J ORCID: 0000-0002-9055-5928, Juonala, M, Pahkala, K, Hutri-Kahonen, N, Kahonen, M, Laitinen, T, Viikari, JSA, Raitakari, OT and Sharman, JE ORCID: 0000-0003-2792-0811 2021 , 'Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life' , Journal of Hypertension, vol. 39, no. 9 , pp. 1865-1875 , doi: 10.1097/HJH.0000000000002855.

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Abstract

Background:Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study.Methods: Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to 3010 participants aged 6–18 years (childhood) who were re-measured up to seven times to mid-adulthood. Markers of cardiovascular end-organ damage in adulthood were carotid intima--media thickness, brachial flow-mediated dilatation, carotid distensibility, pulse wave velocity, left ventricular mass index, carotid plaque, and coronary artery calcification.Results: The mean (standard deviation) cumulative within-visit SBP variability was 2.7 (1.5) mmHg in childhood, 3.9 (1.9) mmHg in adulthood and 3.7 (1.5) mmHg across the observed life-time. Childhood within-visit SBP variability was not correlated with its subsequent values measured from 3 to 31 years later. With adjustment for age, sex, cumulative SBP, BMI and serum lipids, neither child, adult, or life-time cumulative within-visit SBP variability associated with markers of cardiovascular end-organ damage. However, higher child, adult, and life-time cumulative SBP significantly associated with higher carotid intima--media thickness, higher pulse wave velocity, lower brachial flow-mediated dilatation, lower carotid distensibility in adulthood.Conclusion: Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course.

Item Type: Article
Authors/Creators:Meng, Y and Magnussen, CG and Wu, F and Buscot, M-J and Juonala, M and Pahkala, K and Hutri-Kahonen, N and Kahonen, M and Laitinen, T and Viikari, JSA and Raitakari, OT and Sharman, JE
Keywords: blood pressure, hypertension, public health
Journal or Publication Title: Journal of Hypertension
Publisher: Lippincott Williams & Wilkins
ISSN: 0263-6352
DOI / ID Number: 10.1097/HJH.0000000000002855
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